Results
Title

Design and Synthesis of Novel Series of Thiophene-2, 5-dicarbohydrazide Derivatives as Potential Anticancer Agents.

Authors

Gawade, Vaibhav; Chopade, Vitthal

Abstract

Background: The biological activity of thiophene and carbohydrazide derivatives is well known; some of them are included in various anticancer drugs. Objectives: The main goal of this work was to develop effective, effective and non-toxic compounds with anti-cancer properties. To achieve this goal, we synthesized a new series of N2, N5-bis(1E)- ethylidene thiophene-2,5-dicarbohydrazide derivatives. Materials and Methods: Thiophene-2,5-dicarbohydrazide reacts with aromatic aldehydes and ethanol to form a new series of derivatives. This work examined the compounds obtained for them in vitro cytotoxic activity against the breast cancer lines MCF-7. Results: The results of antiproliferative cell inhibition studies showed that some compounds showed high activities compared to standard imatinib drugs. Conclusion: The most promising compounds D1-D10 were selected to study their inhibitory effects on the MCF-7 cell line, where compound D5 showed the highest activity. All synthesized compounds have no adverse effect on normal cell lines.

Subjects

AROMATIC aldehydes; CELL lines; CHEMICAL synthesis; ANTINEOPLASTIC agents; BREAST cancer

Publication

Indian Journal of Pharmaceutical Education & Research, 2024, Vol 58, Issue 3, p837

ISSN

0019-5464

Publication type

Academic Journal

DOI

10.5530/ijper.58.3.92