Results
Title

Anticancer and Hepatoprotective Role of Selenium Nanoparticles against Liver Carcinogen Acrylamide Induced Toxicity: In vitro and in vivo Studies.

Authors

Faridi, Uzma; Zidan, Nahla; Atteia, Hebatallah; Al-Awthan, Yahya; Alalawy, Adel I.; Akhtar, Md. Qussen; Sakran, Mohamed; Parveen, Humaira

Abstract

Background and Objectives: Selenium is considered one of the essential components of many enzymes, particularly the antioxidant enzymes such as thioredoxin reductase. Vegetables, among other food sources, are common sources of selenium. In the present study, the green synthesis of Selenium nanoparticles (SeNPs) from Ocimum basilicum's aerial part was carried out, as were the anticancer and hepatoprotective roles of selenium nanoparticles against liver carcinogen acrylamide-induced toxicity. Materials and Methods: The classification of SeNPs was done by different spectroscopic methods, including UV-spectroscopy, FT-IR, XRD, and HR-TEM. The synthesized SeNPs were tested for their anticancer properties using MTT assays (the normal human liver fibroblast cell line (WISH) and Human liver cancer (HepG2), respectively). Results: The histopathological studies indicated that the liver acrylamide induced in mice showed necrosis and damage in liver cells, but the treatment of mice with SeNPs, reduced the effect of acrylamide significantly. Conclusion: The results indicated the protective effect of SeNPs on acrylamide-induced cells both in vitro and in vivo.

Subjects

LIVER cells; BASIL; ACRYLAMIDE; LIVER cancer; X-ray diffraction

Publication

Indian Journal of Pharmaceutical Education & Research, 2024, Vol 58, Issue 3, p830

ISSN

0019-5464

Publication type

Academic Journal

DOI

10.5530/ijper.58.3.91