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- Title
Hepatoprotective Effect of Silymarin and Propolis in Chemically Induced Chronic Liver Injury in Rats.
- Authors
Hashem, Aml S.; Taha, Nabil M.; Mandour, Abd-Elwahab A.; Lebda, Mohamed A.; Balbaa, Mahmoud E.; El- Morshedy, Amany S.
- Abstract
Silymarin and propolis among phytochemicals that show anti-inflammatory, healing, antioxidant and several other promising properties. Our aim is to investigate protective effect of silymarin and propolis in chemically induced chronic liver injury in rats. A total of 60 male albino rats (90±10 days old) were divided equally into ten groups: (6 rats per each group). The experiment lasted along four months, through which all groups except for group 1 and 6 were given silymarin and propolis. Liver injury was induced in groups 6, 7, 8,9,10 while other groups were injected with saline and oil of the same volume as following. Group 1: served as negative control, the rats were fed on basal ration and water ad libitum. Group 2 (silymarin 100 mg/ kg b.wt). Group 3 (propolis 100 mg/kg b.wt). Group 4 (propolis 150 mg/kg b.wt). Group 5 (propolis 200 mg/kg b.wt). Group 6 served as positive control (DEN CCl4). Group 7 (liver injury silymarin 100 mg/ kg b.wt). Group 8 (liver injury propolis 100 mg /kg b.wt). Group 9 (liver injury propolis 150 mg/kg b.wt). Group 10 (liver injury propolis 200 mg/kg b.wt). Blood samples were collected from all groups after four months and serum samples were separated for biochemical analysis of liver functions and tumor markers Administration of DEN CCl4 significantly increased liver weight, relative liver weight, AST, ALT, ALP, GGT, AFP and CEA while, body weight, total protein, albumin and A/G ratio were markedly decreased. Treatment with silymarin and propolis caused improvement of liver function and reduction of tumor markers. The results indicated a protective effect for silymarin and propolis against hepatic injury induced by DEN CCl4 that may be due to their ability to block the bioactivity of those hepatotoxicants and via their antioxidant properties.
- Subjects
LIVER injuries; THERAPEUTICS; SILYMARIN; PROPOLIS
- Publication
Alexandria Journal of Veterinary Sciences, 2016, Vol 49, Issue 1, p35
- ISSN
1110-2047
- Publication type
Academic Journal
- DOI
10.5455/ajvs.212142