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- Title
A case of rapidly progressive amyotrophic lateral sclerosis associated with SOD1 mutation (p.D126H variant) following COVID-19 vaccination.
- Authors
Chen Fei Ng; Shahrizaila, Nortina; Ahmad-Annuar, Azlina; Edgar, Suzanna; Hui Jan Tan; Remli, Rabani
- Abstract
Mutations in common amyotrophic lateral sclerosis (ALS) genes have been reported in sporadic ALS. In the current case, we describe a patient without known family history who was found to harbour a SOD1 mutation (p.D126H variant) and who developed ALS following COVID-19 vaccination. This mutation has only been previously reported once three decades ago in a British family. Although COVID-19 vaccination in itself is unlikely to contribute to the development of ALS, the possibility that vaccination could play a part in triggering the onset of disease in patients with risk variants merits further study.
- Subjects
AMYOTROPHIC lateral sclerosis; COVID-19 vaccines; FAMILY history (Medicine); GENETIC mutation; VACCINATION
- Publication
Neurology Asia, 2024, Vol 29, Issue 4, p1171
- ISSN
1823-6138
- Publication type
Academic Journal
- DOI
10.54029/2024shv