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Title

FREE RADICALS AND ANTIOXIDANTS: COMPARATIVE IN VITRO STUDY OF CURCUMIN AND XANTHOGREEN™ PRODUCTS TO DEAL WITH OXIDATIVE STRESS.

Authors

Pathak, Sanjivani A.; Sawale, Gayatri D.; Ghuge, Santosh C.; Sathaye, Sadhana

Abstract

Lifestyle disorders caused by imbalanced diet, stress, lack of sleep and exercise disturb the body's homeostasis and cause oxidative stress. The generated reactive radicals damage different organ systems, causing hormonal imbalance, cardiac and respiratory disorders, and neurodegeneration. Our body equips antioxidant enzymes and proteins that scavenge these free radicals to prevent this damage. For better defence against oxidative stress, it is essential to consume antioxidants. This makes it crucial to screen foods from natural sources for their antioxidant activity. Curcumin and Lutein-based derivatives (Xanthogreen™) are the phytochemicals analysed in this research using six different antioxidant assays. It was found that bis-demethoxy curcumin (BDMC) 95 % among the curcumin derivatives; XanthogreenTM Plus, and Lutein ester among the Lutein derivatives had the most significant antioxidant activity. This suggests the potential for developing an adjuvant therapy using these derivatives to target free radicals in treating lifestyle-based disorders.

Subjects

FREE radicals; RADICALS (Chemistry); OXIDATIVE stress; CURCUMIN; HOMEOSTASIS; LUTEIN

Publication

Indian Drugs, 2024, Vol 61, Issue 11, p40

ISSN

0019-462X

Publication type

Academic Journal

DOI

10.53879/id.61.11.14635