Relationship Between Cardiac Autonomic Function and Metabolic Syndrome in Patients with Cardiovascular Disease in Majmaah Region (Kingdom of Saudi Arabia): Case-Control Observational Study.

RIZVI, Moattar Raza; ALBOUGAMI, Abdulrahman

Objective: Lacunae in literature persist regarding the mechanisms connected with the progression from metabolic syndrome (MetS) to Type 2 diabetes and cardiovascular disease (CVD). To validate heart rate variability (HRV), as a tool for progression of CVD in patients visiting cardiovascular outpatient clinic. Material and Methods: This crosssectional study involved screening of 126 patients for the presence of one or more cardiometabolic risk factors and followed with HRV measurement after categorizing them as MetS or control MetS-. Results: Time domain analysis showed a significant reduction between male and female of MetS- and MetS While frequency domain analysis in MetS male showed no difference, MetS female showed significant difference in TP and HF indices. With increasing number of metabolic components, the MetS males exhibited significant decrease in the time domain and increase in frequency domain indices of HRV. Body mass index (BMI), waist circumference (WC), high-density lipoprotein (HDL), and triglyceride (TG) were associated with time and frequency domain of HRV among MetS and MetS- males and females. Low density lipoprotein (LDL) was a significant predictor of SDNN, RRSSD, and NN50 in patients with MetS while HDL was a significant predictor of Standard deviation of normal-to-normal intervals (SDNN) and pNN50. BMI was significant predictor of SDNN and pNN50 in MetS-patients and NN50 in MetS patients. In MetS , the significant predictor of HF was WC, TG, HDL and LDL and that of LF were TG and LDL while in MetS-, WC was significant predictor of LF and HDL of LF/HF. Conclusion: MetS females showed lower vagal activity and decreased sympathetic predominance as compared to MetS males suggesting greater cardiovascular risk.

SAUDI Arabia; METABOLIC syndrome; CARDIOVASCULAR diseases; HEART beat; FREQUENCY-domain analysis; DYSLIPIDEMIA; TIME-domain analysis; DYSAUTONOMIA

Türkiye Klinikleri Cardiovascular Sciences, 1970, Vol 33, Issue 3, p105

1306-7656

Academic Journal

10.5336/cardiosci.2021-84956