Current Advances in Copper MOF as a Potential Third Generation Antibacterial Agent.

Rauf, Abdul; Haroon, Shah Muhammad; Hassan, Mehdi; Raza, Hamid; Anwar, Tehreem; Javed, Mohsin; Mohyuddin, Ayesha; Arshad, Hafiz Muhammad; Imran, Muhammad

Summary: Due to the lack of and high cost of antibacterial medications against resistant bacteria, infectious diseases are the leading cause of death worldwide, especially in low-and middle-income nations. Infectious diseases include viral, parasitic, bacterial, and fungal ones, with bacterial being the most prevalent. The need for the creation of new and effective antibacterial agents is critical because the overuse of antibiotics and the resulting rise in antibiotic resistance persists today. In this context, a number of metals and metal oxides, metal oxide nanoparticles, and metal-organic frameworks (MOFs) are regarded as third-generation antibacterial agents with improved properties in comparison to conventional bactericidal agents and are thought to be a successful remedy to the drug resistance problem. In this review the antibacterial potential of metal nanoparticles, copper and copper oxide nanoparticles, MOF, Cu-MOF, Cu-MOF nanofiberous membrane and Cu-MOF films is explored. The mechanism of these material as antibacterial agent was found as Cu ions release, ROS generations and both Cu metal ions and ROS generations. Based on the performance Cu-MOF, Cu-MOF nanofiberous membrane and Cu-MOF film are the promising third generation antibacterial agent.

METAL nanoparticles; ANTIBIOTIC overuse; METAL-organic frameworks; DRUG resistance in bacteria; DRUG resistance; ANTIBACTERIAL agents

Journal of the Chemical Society of Pakistan, 2024, Vol 46, Issue 6, p574

0253-5106

Academic Journal

10.52568/001617/jcsp/46.06.2024