Objective: to describe the skills and technical-scientific difficulties of Nursing students during the monitoring of Semiotechnics. Method: descriptive study with a quantitative approach. Twenty-nine students from the Nursing Course participated. The monitoring was performed in the Nursing laboratory. Two instruments were elaborated for data collection, then analyzed by descriptive statistics and presented in tables of distribution of absolute and relative frequency. Results: the skills that prevailed in most techniques were the psychomotor and the empowerment of technical-scientific knowledge, both with 44.8%. The difficulty that predominated was the disrespect to the asepsis principle (75.9%). In the initial performance, all the students obtained unsatisfactory classification and, in the final performance, 15 (51.72%) obtained a satisfactory classification. Conclusion: the supervision provided the student with the improvement of the techniques, skills for the professional exercise, interactive learning, reflection based on the problematization and reconstruction of knowledge.