Correlation of Nm23 and P27 Expression in Nodal Diffuse Large B Cell Lymphomas with Clinicopathologic Parameters and the Effect on Prognosis.

Dere, Yelda; Çallı, Aylin Orgen; Alacacıoğlu, İnci; Küçükzeybek, Betül Bolat; Bener, Sadi; Payzın, Bahriye

Objective: Diffuse large B cell lymphoma (DLBCL) is the most common type of adult lymphoma. No certain histopathological parameter was found, except proliferation index, for predicting prognosis. In hematological malignancies, the prognostic effect of Nm23 expression, which shows metastatic potential in solid tumors, has been researched by a few studies. Loss of p27, a negative regulator of the cell cycle, indicates aggressiveness; however, some studies showed that high expression is relevant to poor prognosis. Here, we aimed to investigate whether they can be used as prognostic markers in DLBCLs. Materials and Methods: Forty-two cases were included in the study. Demographic data were collected from hospital records. Manual immunohistochemical staining procedure was performed on one paraffin block of every case. Intensity and percentage of staining were grouped as positive and negative. Results: From 25 males and 17 female patients with a mean age of 62.9, 28 cases (66.7%) were Nm23-positive, and 13 (30.9%) were p27-positive. International Prognostic Index (IPI) score was relevant to prognosis. No significant relationship was found between prognosis and the expression of these two markers. Conclusion: Advanced age, high IPI score, and high serum lactate dehydrogenase (LDH) level were considered poor prognostic factors in DLBCLs. Larger series are needed for using Nm23 and p27 in predicting prognosis because of different results in the literature.

STATISTICAL correlation; GENDER expression; DIFFUSE large B-cell lymphomas; PROGNOSIS; B cell lymphoma; NUCLEOSIDE diphosphate kinases; CYCLIN-dependent kinase inhibitors

Erciyes Medical Journal / Erciyes Tip Dergisi, 2014, Vol 36, Issue 2, p53

2149-2247

Academic Journal

10.5152/etd.2014.7752