Crop productivity is affected by various abiotic and biotic factors. Weeds act as the most serious biological constraint by reducing crop yield, harbouring insect pests and causing serious health hazards. Chemical herbicides were widely employed for weed control in agricultural fields. However, an increase in herbicide-resistant weeds and rising environmental concerns arising from the overuse of synthetic herbicides have led scientists to explore natural ways of managing weeds that are cost-effective and environment-friendly. Ecological control by allelopathic crops has proved to be of great significance in weed management. This review focuses on the problem of herbicide resistance in weeds and the role of allelochemicals in biological weed control. Additionally, the review includes the discussion on the allelopathic potential of various crop plants for weed control which can be exploited for the development of cost-effective and environment-friendly bioherbicide. Further, the discussion on retention and biodegrability of the allelochemicals in rhizosphere along with the studies involving genetic mechanisms underlying allelopathy that will direct the future researches for further progress using allelopathy as a potential tool in sustainable agriculture.