Objective: To compare quality of life (QoL) of patients who received Breast conservation surgery (BCS) to those who underwent Mastectomy. Study Design: A comparative study. Place and Duration of Study: The study took place at Pakistan Institute of Medical Sciences, Islamabad, from Aug 2018 to Sep 2019. Methodology: A comparative study using non probability sampling technique was conducted at Pakistan Institute of Medical Sciences. Quality of life was assessed using a QOL-CSV to evaluate the physical, psychological, social, spiritual well-being as well as distress and fear factors. Data was analyzed using SPSS software 20 and chi square test was applied. Results: Out of a total of 50 cases with mean age of 50.14 ± 4.8 years in Breast conservation group (BCS) and 166 cases with mean age of 54.7 ± 6.3 years were there in mastectomy group. In BCS group there were moderate scores in physical, social, and psychological well-being as well as in fear factor and distress of diagnosis. No comparable difference was observed between both groups with respect to physical, psychological, or spiritual wellbeing, distress score and fear factor. However significant difference was found in the quality of life regarding social concerns. Conclusion: Breast conservation surgery was associated with significant improvements in quality of life scores in terms of social and psychological well-being, with comparable physical and spiritual wellbeing in study population.