Association of moderate aerobic exercise and rho-associated kinase 2 concentration in subjects with dyslipidemia.

Huadong Bai; Jingchun Sun; Guiying Du; Fengjun Jiao; Bai, Huadong; Sun, Jingchun; Du, Guiying; Jiao, Fengjun

Introduction: Dyslipidemia is associated with increased rho-associated kinase 2 (ROCK2) concentration. Whether moderate aerobic exercise could attenuate leukocyte ROCK2 concentration is unknown.Material and Methods: One hundred subjects with dyslipidemia and without statin treatment were enrolled and assigned to exercise and control groups. In the exercise group, at least 30 min of moderate aerobic exercise per day 5 times weekly was recommended. In the control group, participants were recommended to undertake exercise of the same intensity as the exercise group but not mandatorily. At baseline and 3 months later, between-group differences were compared.Results: At baseline, dyslipidemia in both groups was characterized by increased serum levels of total cholesterol and low density lipoprotein cholesterol (LDL-C). Serum high-sensitivity C-reactive protein (hs-CRP) level was comparably increased too, and the average daily exercise time was extremely low: 5.8 ±2.7 min and 6.2 ±3.1 min respectively. Leukocyte ROCK2 concentration in the two groups was 38.4 ±7.5 mg/ml and 40.2 ±8.2 mg/ml respectively. Three months later, compared with the control group, average daily exercise time was significantly longer in the exercise group (37.4 ±4.3 min vs. 16.5 ±7.5 min, p Conclusions: Moderate aerobic exercise could effectively attenuate leukocyte ROCK2 concentration in subjects with dyslipidemia.

DYSLIPIDEMIA; AEROBIC exercises; STATINS (Cardiovascular agents); NITRIC oxide; C-reactive protein; THERAPEUTICS

Archives of Medical Science, 2017, Vol 13, Issue 4, p807

1734-1922

Academic Journal

10.5114/aoms.2017.68142