The changes of platelets counts in atopic dermatitis patients after treatment of abrocitinib: a systematic review and meta-analysis.

Suhua Wu; Boyang Zhou; Xueping Yue; Linfeng Li

This letter to the editor discusses a study on the effects of abrocitinib, a medication used to treat atopic dermatitis, on platelet counts. The study found that abrocitinib treatment resulted in a decrease in platelet counts, with the lowest point occurring at week 4 and gradually returning to normal levels. The higher dose of abrocitinib had a more significant impact on platelet counts. The mechanism behind this effect is not yet understood, and further research is needed to determine the long-term effects and potential risks of abrocitinib treatment. Additionally, the article explores the role of the Ashwell-Morell receptor in regulating the production of thrombopoietin, a protein crucial for platelet production. This research provides valuable insights into platelet production mechanisms and may lead to new treatments for blood clotting disorders.

PLATELET count; ATOPIC dermatitis treatment; JANUS kinases

Advances in Dermatology & Allergology / Postępy Dermatologii i Alergologii, 2024, Vol 41, Issue 2, p232

1642-395X

Academic Journal

10.5114/ada.2024.138659