A review of intralesional wart therapy.

Muse, Mikél E.; Stiff, Katherine M.; Glines, Katelyn R.; Cline, Abigail; Feldman, Steven R.

Background: New treatment options for warts include intralesional wart injection with agents such as vitamin D, measles, mumps, and rubella (MMR) vaccine antigen, Bacillus Calmette-Guerin (BCG) antigen, and Candida antigen but there have been limited studies to compare their efficacies. Background: New treatment options for warts include intralesional wart injection with agents such as vitamin D, measles, mumps, and rubella (MMR) vaccine antigen, Bacillus Calmette-Guerin (BCG) antigen, and Candida antigen but there have been limited studies to compare their efficacies. Objective: The purpose of this systematic review is to compare the efficacy and safety of injectable agents used for the treatment of warts. Methods: A PubMed search included terms "intralesional wart therapy," "wart injection" and "verruca injection." Articles reviewed were published over 10 years. Results: A total of 43 articles were reviewed; 30 covered studies with more than 10 participants and 13 were case reports, case series, and reviews. In comparison studies intralesional agents have equal or superior efficacy (66%-94.9%) compared to firstline salicylic acid or cryotherapy (65.5-76.5%). One advantage of intralesional injections is the rate of complete resolution of distant warts. Limitations: Each study varied in their agents, treatment interval, and treatment dose, making comparisons difficult. Conclusions: Intralesional wart injections are safe, affordable, and efficacious treatments for warts. Physicians should consider intralesional injections for patients with refractory warts, multiple warts, or warts in sensitive areas.

WARTS treatment; INJECTIONS; BCG vaccines; ANTIGEN analysis; COLD therapy; SALICYLIC acid

Dermatology Online Journal, 2020, Vol 26, Issue 3, p1

1087-2108

Academic Journal

10.5070/d3263048027