Title: Levodopa-induced myocardial infarction in a patient with Parkinson's disease and severe coronary artery disease.
Authors: Chen Fei Ng; Patrick WJ Tiau; Hui Jan Tan; MI Norlinah
Abstract: Levodopa is the most effective medical treatment for Parkinson's disease (PD) to date. As dopamine is known to increase cardiac inotropism and vasomotor tone, peripheral dopamine decarboxylase inhibitor is coadministered to suppress the peripheral conversion of levodopa to dopamine. Levodopa poses potential cardiovascular risks, thus its use in patients with existing coronary artery disease needs to be carefully monitored. We report a case of an elderly male with newly diagnosed PD who developed non-ST-elevation myocardial infarction following levodopa (Madopar) initiation.
Subjects: DOPA; PARKINSON'S disease treatment; CORONARY disease; MYOCARDIAL infarction; DRUG efficacy
Publication: Journal of the Royal College of Physicians of Edinburgh, 2019, Vol 49, Issue 1, p37
ISSN: 1478-2715
Publication type: Academic Journal
DOI: 10.4997/JRCPE.2019.108

Levodopa-induced myocardial infarction in a patient with Parkinson's disease and severe coronary artery disease.

Chen Fei Ng; Patrick WJ Tiau; Hui Jan Tan; MI Norlinah