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- Title
Pathology and Diagnosis of Ocular Squamous Cell Carcinoma in Bovines.
- Authors
Kumar, Vivek; Jolhe, Dhananjay Kumar; Ghosh, Ratan Chandra; Sonkusale, Prashant M.; Sharma, Sonu
- Abstract
An investigation was carried out on 6 clinical cases of neoplasm of eye in bovines suspected of ocular squamous cell carcinoma (OSCC) which revealed the pathomorphological features and immunohistochemical expression of Pan-cytokeratin (Pan-CK), p53, epidermal growth factor receptor (EGFR) and p16, and confirmed OSCC in 3 out of 6 (50%) cases. Two cases were confirmatory in HF cattle and one in Murrah buffalo. Grossly, unilateral large firm cauliflower like growth, congested and reddish protruded mass of tissue covering the whole cornea resulted in blindness. Large nodular, hemorrhagic growth on limbus and lower eyelid with verrucous surface was also observed. OSCCs were classified into well, moderately and poorly differentiated types on the basis of histopathology and immunohistochemistry (IHC). Histopathological findings were distinctive keratin pearls with concentric layers of keratinization observed in well differentiated OSCC. Absence of epithelial pearls, although with numerous mitotic figures with evidences of anaplasia and neovascularization were observed in poorly differentiated OSCC, and moderate degree of keratinization at the center of neoplastic islets in moderately differentiated OSCC. The highest IHC expression was observed in Pan-CK, which confirmed the tumours of epithelial origin and EGFR was confirmatory for malignancy and degree of metastasis. Expression of Pan-CK in well differentiated OSCC revealed strong immunoreactivity towards Pan-CK. High immunoreactivity against EGFR with strong expression of EGFR was seen in moderately differentiated OSCC and mild immunoreaction in poorly differentiated OSCC. Mild immunoreaction for p16 was observed in one case. Thus, the neoplasms of eye can be confirmed as OSCC by immunoexpression of Pan-CK, EGFR, p16 and p53 in malignant tumours.
- Subjects
EPIDERMAL growth factor receptors; SQUAMOUS cell carcinoma; KERATINIZATION; KERATIN; CORNEA
- Publication
Indian Journal of Veterinary Sciences & Biotechnology, 2023, Vol 19, Issue 4, p43
- ISSN
2394-0247
- Publication type
Academic Journal
- DOI
10.48165/ijvsbt.19.4.09