Enamel defects are disturbances in enamel formation that arise during odontogenesis in formation of hypoplasia and hipomineralization. Atopic dermatitis is chronic skin disease occurred due to disorders of epidermal tissue and imune system. Goal of this study was to explain the possible correlation between enamel defect and atopic dermatitis in children. Literature search was performed on these databases: Pubmed, ResearchGate, Semantic Scholar, and SagePub with keywords: email defect, atopic dermatitis, hypomineralization, and hypoplasia. After analizing, five studies were selected for this literature review. From reviewing of five studies, it was found that there is a relationship between email defects and atopic dermatitis. In prenatal development, origins of skin and enamel are the same, namely epithelial cells produced from ectodermal cells, therefore, email defects and atopic dermatitis can occur simultaneously. There is a correlation between email defects and atopic dermatitis.