Works matching DE "SIGMA-1 receptor"

Results: 117

Repurposing Sigma-1 Receptor-Targeting Drugs for Therapeutic Advances in Neurodegenerative Disorders.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 5, p. 700, doi. 10.3390/ph18050700

By:

Eskandari, Kiarash;
Bélanger, Sara-Maude;
Lachance, Véronik;
Kourrich, Saïd

Publication type:

Article

Suppression of SIGMAR1 hinders oral cancer cell growth via modulation of mitochondrial Ca2+ dynamics.

Published in:

Molecular Biology Reports, 2025, v. 52, n. 1, p. 1, doi. 10.1007/s11033-025-10336-2

By:

Chagas, Pablo Shimaoka;
Garcia, Cristiana Bernadelli;
Chagas, Henrique Izumi Shimaoka;
Yeudall, W. Andrew;
Yu, Jack C.;
Baban, Babak;
Leopoldino, Andréia Machado

Publication type:

Article

New Long-Term Data Suggest Continued Blarcamesine Efficacy in Alzheimer Disease Up to 4 Years.

Published in:

Patient Care (Online), 2025, p. 1

By:

Halsey, Grace

Publication type:

Article

Psychomotor Symptoms, Cognitive Impairments, and Suicidal Thoughts after COVID-19 Infection: A Case Report and Possible Allostatic Mechanism.

Published in:

2024

By:

Lin, Ying;
Lin, Chen;
Chang, Jason Hong-Yi;
Chiang, Dai-Lun;
Lai, Feipei;
Lin, Chen-Ju

Publication type:

Case Study

Sigma 1 receptor modulators as a new weapon against multiple sclerosis.

Published in:

BioDiscovery, 2017, p. 1, doi. 10.3897/biodiscovery.20.e14565

By:

Collina, Simona;
Rui, Marta;
Rossino, Giacomo;
Volpe, Serena Della;
Rossi, Daniela;
Scuteri, Arianna;
Malacrida, Alessio;
Cavaletti, Guido

Publication type:

Article

Neurosteroids and neurological disorders.

Published in:

2025

By:

Gi Wan Park;
Hayoung Kim;
Seong Hyun Won;
Nam Hyun Kim;
Sheu-Ran Choi

Publication type:

Literature Review

ALSUntangled #71: Nuedexta.

Published in:

Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, 2024, v. 25, n. 1/2, p. 218, doi. 10.1080/21678421.2023.2239292

By:

Sun, Yuyao;
Benatar, Michael;
Mascías Cadavid, Javier;
Ennist, Dave;
Wicks, Paul;
Staats, Kim;
Beauchamp, Morgan;
Jhooty, Sartaj;
Pattee, Gary;
Brown, Andrew;
Bertorini, Tulio;
Barkhaus, Paul;
Bromberg, Mark;
Carter, Greg;
Bedlack, Richard;
Li, Xiaoyan

Publication type:

Article

Sigma-1 Receptor Modulates Neuroinflammation After Traumatic Brain Injury.

Published in:

Cellular & Molecular Neurobiology, 2016, v. 36, n. 5, p. 639, doi. 10.1007/s10571-015-0244-0

By:

Dong, Hui;
Ma, Yunfu;
Ren, Zengxi;
Xu, Bin;
Zhang, Yunhe;
Chen, Jing;
Yang, Bo

Publication type:

Article

A possibly sigma-1 receptor mediated role of dimethyltryptamine in tissue protection, regeneration, and immunity.

Published in:

Journal of Neural Transmission, 2013, v. 120, n. 9, p. 1295, doi. 10.1007/s00702-013-1024-y

By:

Frecska, Ede;
Szabo, Attila;
Winkelman, Michael;
Luna, Luis;
McKenna, Dennis

Publication type:

Article

Exploring the Association between Schizophrenia and Cardiovascular Diseases: Insights into the Role of Sigma 1 Receptor.

Published in:

Physiological Research, 2023, v. 72, p. S113, doi. 10.33549/physiolres.935099

By:

RAFCIKOVA, Julie;
NOVAKOVA, Marie;
STRACINA, Tibor

Publication type:

Article

Sigma-1 Receptor as a Novel Therapeutic Target in Diabetic Kidney Disease.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 24, p. 13327, doi. 10.3390/ijms252413327

By:

Balogh, Dora B.;
Hodrea, Judit;
Saeed, Adar;
Cserhalmi, Marcell;
Rozsahegyi, Alexandra;
Lakat, Tamas;
Lenart, Lilla;
Szabo, Attila J.;
Wagner, Laszlo J.;
Fekete, Andrea

Publication type:

Article

Sigma-1 receptor targeting inhibits connexin 43 based intercellular communication in chronic neuropathic pain.

Published in:

Inflammation Research, 2024, v. 73, n. 10, p. 1711, doi. 10.1007/s00011-024-01926-0

By:

Denaro, Simona;
D'Aprile, Simona;
Torrisi, Filippo;
Zappalà, Agata;
Marrazzo, Agostino;
Al-Khrasani, Mahmoud;
Pasquinucci, Lorella;
Vicario, Nunzio;
Parenti, Rosalba;
Parenti, Carmela

Publication type:

Article

Normalization of Calcium Balance in Striatal Neurons in Huntington's Disease: Sigma 1 Receptor as a Potential Target for Therapy.

Published in:

Biochemistry (00062979), 2021, v. 86, n. 4, p. 471, doi. 10.1134/S0006297921040076

By:

Kraskovskaya, Nina A.;
Bezprozvanny, Ilya B.

Publication type:

Article

Stranger Twins: A Tale of Resemblance and Contrast Between VAP Proteins.

Published in:

Contact (25152564), 2023, v. 6, p. 1, doi. 10.1177/25152564231183897

By:

Subra, Mélody;
Grimanelli, Zoé;
Gautier, Romain;
Mesmin, Bruno

Publication type:

Article

Sigma 1 Receptor, Cholesterol and Endoplasmic Reticulum Contact Sites.

Published in:

Contact (25152564), 2021, v. 4, p. 1, doi. 10.1177/25152564211026505

By:

Zhemkov, Vladimir;
Liou, Jen;
Bezprozvanny, Ilya

Publication type:

Article

Cardiac 11C-Donepezil Binding Increases With Age in Healthy Humans: Potentially Signifying Sigma-1 Receptor Upregulation.

Published in:

2019

By:

Horsager, Jacob;
Fedorova, Tatyana D.;
Berge, Nathalie V.D.;
Klinge, Mette W.;
Knudsen, Karoline;
Hansen, Allan K.;
Alstrup, Aage K.O.;
Krogh, Klaus;
Gormsen, Lars;
Borghammer, Per

Publication type:

journal article

The role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains.

Published in:

eLife, 2021, p. 1, doi. 10.7554/eLife.65192

By:

Zhemkov, Vladimir;
Ditlev, Jonathon A.;
Wan-Ru Lee;
Wilson, Mikaela;
Liou, Jen;
Rosen, Michael K.;
Bezprozvanny, Ilya

Publication type:

Article

Effects of the sigma-1 receptor agonist blarcamesine in a murine model of fragile X syndrome: neurobehavioral phenotypes and receptor occupancy.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-94079-7

By:

Reyes, Samantha T.;
Deacon, Robert M. J.;
Guo, Scarlett G.;
Altimiras, Francisco J.;
Castillo, Jessa B.;
van der Wildt, Berend;
Morales, Aimara P.;
Park, Jun Hyung;
Klamer, Daniel;
Rosenberg, Jarrett;
Oberman, Lindsay M.;
Rebowe, Nell;
Sprouse, Jeffrey;
Missling, Christopher U.;
McCurdy, Christopher R.;
Cogram, Patricia;
Kaufmann, Walter E.;
Chin, Frederick T.

Publication type:

Article

Why N,N-dimethyltryptamine matters: unique features and therapeutic potential beyond classical psychedelics.

Published in:

Frontiers in Psychiatry, 2024, p. 1, doi. 10.3389/fpsyt.2024.1485337

By:

Chaves, Cristiano;
dos Santos, Rafael G.;
Dursun, Serdar M.;
Tusconi, Massimo;
Carta, Mauro Giovanni;
Brietzke, Elisa;
Hallak, Jaime E. C.

Publication type:

Article

Why N,N-dimethyltryptamine matters: unique features and therapeutic potential beyond classical psychedelics.

Published in:

Frontiers in Psychiatry, 2024, p. 1, doi. 10.3389/fpsyt.2024.1485337

By:

Chaves, Cristiano;
dos Santos, Rafael G.;
Dursun, Serdar M.;
Tusconi, Massimo;
Carta, Mauro Giovanni;
Brietzke, Elisa;
Hallak, Jaime E. C.

Publication type:

Article

Mechanisms and treatments of methamphetamine and HIV-1 co-induced neurotoxicity: a systematic review.

Published in:

Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1423263

By:

Lin Miao;
Haowei Wang;
Yi Li;
Jian Huang;
Chan Wang;
Hanxin Teng;
Lisha Xu;
Xue Yang;
Yunqing Tian;
Genmeng Yang;
Xiaofeng Zeng;
Juan Li

Publication type:

Article

Pridopidine in Amyotrophic Lateral Sclerosis: The HEALEY ALS Platform Trial.

Published in:

JAMA: Journal of the American Medical Association, 2025, v. 333, n. 13, p. 1128, doi. 10.1001/jama.2024.26429

By:

Shefner, Jeremy M.;
Oskarsson, Björn;
Macklin, Eric A.;
Chibnik, Lori B.;
Quintana, Melanie;
Saville, Benjamin R.;
Detry, Michelle A.;
Vestrucci, Matteo;
Marion, Joe;
McGlothlin, Anna;
Heiman-Patterson, Terry;
Chase, Marianne;
Pothier, Lindsay;
Harkey, Brittney A.;
Yu, Hong;
Sherman, Alexander V.;
Hall, Meghan;
Kittle, Gale;
Berry, James D.;
Babu, Suma

Publication type:

Article

Platform Trials in ALS.

Published in:

2025

By:

Turnbull, John

Publication type:

Editorial

Psychedelic N,N-Dimethyltryptamine and 5-Methoxy-N,N-Dimethyltryptamine Modulate Innate and Adaptive Inflammatory Responses through the Sigma-1 Receptor of Human Monocyte-Derived Dendritic Cells.

Published in:

PLoS ONE, 2014, v. 9, n. 8, p. 1, doi. 10.1371/journal.pone.0106533

By:

Szabo, Attila;
Kovacs, Attila;
Frecska, Ede;
Rajnavolgyi, Eva

Publication type:

Article

Involvement of Sigma-1 Receptors in the Antidepressant-like Effects of Dextromethorphan.

Published in:

PLoS ONE, 2014, v. 9, n. 2, p. 1, doi. 10.1371/journal.pone.0089985

By:

Nguyen, Linda;
Robson, Matthew J.;
Healy, Jason R.;
Scandinaro, Anna L.;
Matsumoto, Rae R.

Publication type:

Article

Sigma-1 Receptor Chaperone at the ER-Mitochondrion Interface Mediates the Mitochondrion-ER-Nucleus Signaling for Cellular Survival.

Published in:

PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0076941

By:

Mori, Tomohisa;
Hayashi, Teruo;
Hayashi, Eri;
Su, Tsung-Ping

Publication type:

Article

Sigma-1 Receptor Enhances Neurite Elongation of Cerebellar Granule Neurons via TrkB Signaling.

Published in:

PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0075760

By:

Kimura, Yuriko;
Fujita, Yuki;
Shibata, Kumi;
Mori, Megumi;
Yamashita, Toshihide

Publication type:

Article

Potentiation of Nerve Growth Factor-Induced Neurite Outgrowth by Fluvoxamine: Role of Sigma-1 Receptors, IP3 Receptors and Cellular Signaling Pathways.

Published in:

PLoS ONE, 2008, v. 3, n. 7, p. 1, doi. 10.1371/journal.pone.0002558

By:

Nishimura, Tomoko;
Ishima, Tamaki;
Iyo, Masaomi;
Hashimoto, Kenji

Publication type:

Article

The Endogenous Hallucinogen and Trace Amine N,N-Dimethyltryptamine (DMT) Displays Potent Protective Effects against Hypoxia via Sigma-1 Receptor Activation in Human Primary iPSC-Derived Cortical Neurons and Microglia-Like Immune Cells.

Published in:

Frontiers in Neuroscience, 2016, p. 1, doi. 10.3389/fnins.2016.00423

By:

Szabo, Attila;
Rajnavolgyi, Eva;
Kovacs, Attila;
Frecska, Ede;
Riba, Jordi;
Djurovic, Srdjan

Publication type:

Article

Mutated sigma-1R disrupts cell homeostasis in dHMN patient cells.

Published in:

Cellular & Molecular Life Sciences, 2025, v. 82, n. 1, p. 1, doi. 10.1007/s00018-025-05676-y

By:

Zanin, Sofia;
Ciscato, Francesco;
Petrucci, Antonio;
Botta, Annalisa;
Chiossi, Federico;
Vazza, Giovanni;
Rizzuto, Rosario;
Pallafacchina, Giorgia

Publication type:

Article

Point Mutation in Sigma-1 Receptor Inhibits Neuronal Cell Differentiation.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A992

By:

Yahong Zhang;
Kim, Felix J.;
Pasternak, Gavril W.

Publication type:

Article

Sigma-1 receptors and progesterone metabolizing enzymes in nociceptive sensory neurons of the female rat trigeminal ganglia: A neural substrate for the antinociceptive actions of progesterone.

Published in:

Molecular Pain, 2022, p. 1, doi. 10.1177/17448069211069255

By:

Hornung, Rebecca S;
Raut, Namrata GR;
Cantu, Daisy J;
Lockhart, Lauren M;
Averitt, Dayna L

Publication type:

Article

Sigma-1 receptor antagonist haloperidol attenuates Ca responses induced by glutoxim and molixan in macrophages.

Published in:

Doklady Biochemistry & Biophysics, 2017, v. 472, n. 1, p. 74, doi. 10.1134/S1607672917010227

By:

Krutetskaya, Z.;
Milenina, L.;
Naumova, A.;
Butov, S.;
Antonov, V.;
Nozdrachev, A.

Publication type:

Article

Central role of Sigma-1 receptor in ochratoxin A-induced ferroptosis.

Published in:

Archives of Toxicology, 2024, v. 98, n. 10, p. 3323, doi. 10.1007/s00204-024-03805-3

By:

Chen, Wenying;
Han, Lingyun;
Yang, Ruiran;
Wang, Hongwei;
Yao, Song;
Deng, Huiqiong;
Liu, Shuangchao;
Zhou, Yao;
Shen, Xiao Li

Publication type:

Article

Sigma-1 receptor ligand PD144418 and sigma-2 receptor ligand YUN-252 attenuate the stimulant effects of methamphetamine in mice.

Published in:

Psychopharmacology, 2019, v. 236, n. 11, p. 3147, doi. 10.1007/s00213-019-05268-2

By:

Tapia, Melissa A.;
Lever, John R.;
Lever, Susan Z.;
Will, Matthew J.;
Park, Eric S.;
Miller, Dennis K.

Publication type:

Article

The role of sigma-1 receptor and brain-derived neurotrophic factor in the development of diabetes and comorbid depression in streptozotocin-induced diabetic rats.

Published in:

Psychopharmacology, 2016, v. 233, n. 7, p. 1269, doi. 10.1007/s00213-016-4209-x

By:

Lenart, Lilla;
Hodrea, Judit;
Hosszu, Adam;
Koszegi, Sandor;
Zelena, Dora;
Balogh, Dora;
Szkibinszkij, Edgar;
Veres-Szekely, Apor;
Wagner, Laszlo;
Vannay, Adam;
Szabo, Attila;
Fekete, Andrea

Publication type:

Article

Sigma 1 receptor activation regulates brain-derived neurotrophic factor through NR2A-CaMKIV-TORC1 pathway to rescue the impairment of learning and memory induced by brain ischaemia/reperfusion.

Published in:

Psychopharmacology, 2015, v. 232, n. 10, p. 1779, doi. 10.1007/s00213-014-3809-6

By:

Xu, Qian;
Ji, Xue-Fei;
Chi, Tian-Yan;
Liu, Peng;
Jin, Ge;
Gu, Shao-Li;
Zou, Li-Bo

Publication type:

Article

Dose-dependent sigma-1 receptor occupancy by donepezil in rat brain can be assessed with C-SA4503 and microPET.

Published in:

Psychopharmacology, 2014, v. 231, n. 20, p. 3997, doi. 10.1007/s00213-014-3533-2

By:

Ramakrishnan, Nisha;
Visser, Anniek;
Schepers, Marianne;
Luurtsema, Gert;
Nyakas, Csaba;
Elsinga, Philip;
Ishiwata, Kiichi;
Dierckx, Rudi;
Waarde, Aren

Publication type:

Article

Disruptions in serotonin- and kynurenine pathway metabolism in post-COVID: biomarkers and treatment.

Published in:

Frontiers in Neurology, 2025, p. 1, doi. 10.3389/fneur.2025.1532383

By:

Rus, Carla P.

Publication type:

Article

Sigma-1 receptor concentration in plasma of patients with late-life depression: a preliminary study.

Published in:

Neuropsychiatric Disease & Treatment, 2013, v. 9, p. 1867, doi. 10.2147/NDT.S53386

By:

Hideyuki Shimizu;
Minoru Takebayashi;
Masayuki Tani;
Hiroaki Tanaka;
Bun Yamagata;
Kenzo Kurosawa;
Hiroki Yamada;
Mitsugu Hachisu;
Kazue Hisaoka-Nakashima;
Mami Okada-Tsuchioka;
Masaru Mimura;
Akira Iwanami

Publication type:

Article

Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine.

Published in:

Autophagy, 2023, v. 19, n. 1, p. 126, doi. 10.1080/15548627.2022.2063003

By:

Wang, Shao-Ming;
Wu, Hsiang-En;
Yasui, Yuko;
Geva, Michal;
Hayden, Michael;
Maurice, Tangui;
Cozzolino, Mauro;
Su, Tsung-Ping

Publication type:

Article

Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism.

Published in:

Brain: A Journal of Neurology, 2014, v. 137, n. 7, p. 1998, doi. 10.1093/brain/awu107

By:

Francardo, Veronica;
Bez, Francesco;
Wieloch, Tadeusz;
Nissbrandt, Hans;
Ruscher, Karsten;
Cenci, M. Angela

Publication type:

Article

NMDA Receptors Are Upregulated and Trafficked to the Plasma Membrane after Sigma-1 Receptor Activation in the Rat Hippocampus.

Published in:

Journal of Neuroscience, 2014, v. 34, n. 34, p. 11325, doi. 10.1523/JNEUROSCI.0458-14.2014

By:

Pabba, Mohan;
Wong, Adrian Y. C.;
Ahlskog, Nina;
Hristova, Elitza;
Biscaro, Dante;
Nassrallah, Wissam;
Ngsee, Johnny K.;
Snyder, Melissa;
Beique, Jean-Claude;
Bergeron, Richard

Publication type:

Article

Can Sertraline Induced Constipation be Sigma 1 Receptors Mediated and Dose Depended?

Published in:

Yeni Symposium, 2020, v. 58, n. 4, p. 40, doi. 10.5455/NYS.20210406054523

By:

ALTUNÇ, Ali Tarık;
KAVLA, Yasin;
TURAN, Şenol

Publication type:

Article

Ayahuasca and its interaction with the sigma-1 receptor: a potential treatment for COVID-19.

Published in:

Brazilian Journal of Psychiatry / Revista Brasileira de Psiquiatria, 2022, v. 44, n. 4, p. 465, doi. 10.47626/1516-4446-2022-2541

By:

Escobar-Cornejo, Guillermo Saúl;
Escobar-Cornejo, Diego Mauricio;
Ramos-Vargas, Luis Fernando

Publication type:

Article

Stalking in clinical psychiatry: when the doctor becomes the victim.

Published in:

Brazilian Journal of Psychiatry / Revista Brasileira de Psiquiatria, 2022, v. 44, n. 4, p. 464, doi. 10.47626/1516-4446-2022-2464

By:

Soledade Signori, João Pedro;
do Canto, Gustavo Cambraia;
Roza, Thiago Henrique;
de Borba Telles, Lisieux Elaine;
de Almeida Fleck, Marcelo Pio

Publication type:

Article

High specific activity tritium labelling of some sigma-1 receptor agonists.

Published in:

Journal of Radioanalytical & Nuclear Chemistry, 2012, v. 292, n. 1, p. 19, doi. 10.1007/s10967-011-1369-3

By:

Ahern, David;
Seguin, Richard;
Filer, Crist

Publication type:

Article

Induction of Hypothermic Conditions Associated with Increased Micronuclei Formation in Sigma-1 Receptor Knockout Mice after Administration of the Antipsychotic Compound E-5842.

Published in:

Environmental & Molecular Mutagenesis, 2008, v. 49, n. 9, p. 727, doi. 10.1002/em.20428

By:

Guzmán, Antonio;
Marín, Ana-Paz;
García, Concepción;
Fernández de Henestrosa, Antonio R.;
Ruiz, María Teresa;
Tortajada, Araceli;
Marcos, Ricard

Publication type:

Article

Sigma 1 Receptor Antagonists Inhibit Manic-Like Behaviors in Two Congenital Strains of Mice.

Published in:

International Journal of Neuropsychopharmacology, 2018, v. 21, n. 10, p. 938, doi. 10.1093/ijnp/pyy049

By:

Sánchez-Blázquez, Pilar;
Cortés-Montero, Elsa;
Rodríguez-Muñoz, María;
Garzón, Javier

Publication type:

Article

Why sigma-1 receptor dysfunction might confer vulnerability to cannabis-induced psychosis.

Published in:

International Journal of Neuropsychopharmacology, 2014, v. 17, n. 12, p. 1911, doi. 10.1017/S1461145714000960

By:

Arnold, Jonathon C.

Publication type:

Article