Background: Dengue Hemorrhagic Fever (DHF) is a tropical disease still a global public health problem. Dengue fever is found worldwide, especially in tropical and subtropical countries. Objective: The study aims to analyze the spatial correlation of dengue incidence in Palopo City, Indonesia, in 2022. Methods: It was quantitative research using ecological studies. Results: Spatial analysis showed that high DHF incidence was found in very high population density (401-1 000 people), high coverage of healthy houses (=80 %), moderate poverty (143-218 people), close to health care facilities (<1 000 m), low elevation (7.0-16.70 m above sea level), high mobility (67-73 people). There was a significant correlation between DHF incidence and population density (r=0.444; p=0.001), health service facilities (r=0.541; p=0.0001), elevation (r= -0.293; p=0.043), mobility (r=0.306; p=0.033). There was no correlation between DHF incidence and the coverage of healthy houses (r=0.135; p=0.359) and poverty (r=0.123; p=0.402). Conclusion. Population density, distance to healthcare facilities, elevation, and population mobility influence DHF incidence in Palopo City, Indonesia, 2022.