Antioxidant, biofilm inhibition and mutagenic activities of newly substituted fibrates.

Sheikh, Asma; Zia-Ur-Rehman; Imran, Muhammad; Mahmood, Zaid

Purpose: A series of benzylidene-2-(4-bromophenoxy)-2-methyl propane hydrazides (1-10) were synthesized and assay them for their biofilm inhibition, antioxidant and mutagenic. Methods: All derivatives were prepared by condensation of various substituted benzaldehyde and acetophenones with 2-(4-bromorophenoxy)-2-methyl propane hydrazide, which was itself prepared by hydrazinolysis of ethyl-2-(4-bromophenoxy)-2-methyl propanoate and were characterized by FTIR, ¹H NMR 13C NMR, mass spectrometry. They were screened for their in-vitro anti-oxidant, biofilm inhibition and mutagenicity by established methods. Results: Anti-oxidant results revealed that the electron donating group enhanced the scavenging ability of the compounds as seen in compounds 4b, 4h and 4i. In biofilm inhibition studies, all compounds were more active against Gram-ive bacterial strain when compared to gram ive strain. The mutagenicity assay results indicate that the compound having chloro group substitution is mutagenic. Conclusion: The benzylidine compounds of 2-(4-bromophenoxy)-2-methyl hydrazide possessing electron donating substituents exhibit superior activities to the electron withdrawing group substituents.

PERMUTATION groups; PHARMACEUTICAL research; HYDRAZONE derivatives; MASS spectrometry; ACETOPHENONE; ANTIOXIDANTS

Tropical Journal of Pharmaceutical Research, 2019, Vol 18, Issue 6, p1227

1596-5996

Academic Journal

10.4314/tjpr.v18i6.12