Results
Title

Hydroxypropyl cellulose-based orally disintegrating films of promethazine HCl for the treatment of motion sickness.

Authors

Hussain, Amjad; Latif, Sadia; Abbas, Nasir; Irfan, Muhammad; Arshad, Muhammad Sohail; Bukhari, Nadeem Irfan

Abstract

Purpose: To prepare and characterize orally disintegrating films (ODFs) of promethazine hydrochloride (HCl) for prompt treatment of motion sickness. Methods: Films were prepared by solvent casting method using hydroxypropyl cellulose (HPC) as film former and glycerin as plasticizer along with a saliva stimulating and sweetening agent. Nine different film formulations were prepared and evaluated for their characteristics including thickness, disintegration time, tensile strength and drug release behavior. Results: The prepared films were transparent and slightly sticky in nature with thickness that ranged from 0.22 mm to 0.29 mm and tensile strength of 0.56 N/cm2 to 2.49 N/cm2. The disintegration time of film formulations ranged from 26.3 to 52.7 s and a majority of formulations released approx. 80 % of the drug within 10 min with a non-Fickian diffusion pattern. Conclusion: The study concludes that the orally disintegrating films of promethazine HCl can be prepared using HPC as film former.

Subjects

MOTION sickness treatment; PROMETHAZINE; HYDROXYPROLINE; SALIVA analysis; ANTIEMETICS

Publication

Tropical Journal of Pharmaceutical Research, 2018, Vol 17, Issue 6, p991

ISSN

1596-5996

Publication type

Academic Journal

DOI

10.4314/tjpr.v17i6.2