DRESS sendromlu 11 olgunun klinik özelliklerinin incelenmesi.

Emre, Selma; Akoğlu, Gülşen; Metin, Ahmet; Demirseren, Duriye Deniz; Kurtoğlu, Gözde

Background and Design: DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) syndrome is a severe reaction induced by drugs and accompanied by cutaneous, hematologic and solid organ involvement. Since the syndrome requires specific treatments and has high mortality rates, early diagnosis is very important. In our country, any descriptive study has not been reported about patients with DRESS syndrome except for a few case presentations. Therefore, we aimed to investigate the clinical characteristics of patients with DRESS syndrome diagnosed and treated in our inpatient clinic. Materials and Methods: The records of patients diagnosed with DRESS syndrome or drug eruption were retrospectively analyzed. Scoring system created by a RegiSCAR group was used. Patients with certain, probable and possible DRESS syndrome were identified. Clinical features, laboratory findings and etiological factors were noted. Results: Seven males and 4 females with DRESS syndrome were enrolled. Four patients were identified as definite case and seven were probable DRESS syndrome. Aromatic anticonvulsants were the only responsible drugs (phenytoin in 5, carbamezepine in 3, lamotrigine in 3 patients). All patients had cutaneous manifestations and hematological abnormalities. Fever, liver function impairment, lymphadenopathy, renal disease and pneumonia were the clinical findings in order of frequency. Cessation of responsible drugs and treatment with systemic corticosteroids achieved full remission in all patients. Conclusion: DRESS syndrome may present with various clinical manifestations. Because signs and symptoms form the basis for recognition of the disease, good knowledge of clinical features is important in early diagnosing DRESS syndrome and reducing mortality and morbidity.

ADRENOCORTICAL hormones; HORMONE therapy; ANTICONVULSANTS; RETROSPECTIVE studies; DESCRIPTIVE statistics; DRESS syndrome; DIAGNOSIS

Archives of the Turkish Dermatology & Venerology / Turkderm, 2013, Vol 47, Issue 4, p218

1019-214X

Academic Journal

10.4274/turkderm.71324