OpenURL Connection Search

Select item for more details and to access through your institution.

P2X<sub>7</sub> receptor antagonism ameliorates renal dysfunction in a rat model of sepsis.
Published in:
Physiological Reports, 2018, v. 6, n. 5, p. 1, doi. 10.14814/phy2.13622
By:
- Arulkumaran, Nishkantha;
- Sixma, Marije L.;
- Pollen, Sean;
- Ceravola, Elias;
- Jentho, Elisa;
- Prendecki, Maria;
- Bass, Paul S.;
- Tam, Frederick. W. K.;
- Unwin, Robert J.;
- Singer, Mervyn
Publication type:
Article
A randomised controlled trial of plasma exchange compared to standard of care in the treatment of severe COVID-19 infection (COVIPLEX).
Published in:
Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-67028-3
By:
- Arulkumaran, Nishkantha;
- Thomas, Mari;
- Stubbs, Matthew;
- Prasanna, Nithya;
- Subhan, Maryam;
- Singh, Deepak;
- Ambler, Gareth;
- Waller, Alessia;
- Singer, Mervyn;
- Brealey, David;
- Scully, Marie
Publication type:
Article
Intracellularly Released Cholesterol from Polymer-Based Delivery Systems Alters Cellular Responses to Pneumolysin and Promotes Cell Survival.
Published in:
Metabolites (2218-1989), 2021, v. 11, n. 12, p. 821, doi. 10.3390/metabo11120821
By:
- Kammann, Tobias;
- Hoff, Jessica;
- Yildirim, Ilknur;
- Shkodra, Blerina;
- Müller, Tina;
- Weber, Christine;
- Gräler, Markus H.;
- Maus, Ulrich A.;
- Paton, James C.;
- Singer, Mervyn;
- Traeger, Anja;
- Schubert, Ulrich S.;
- Bauer, Michael;
- Press, Adrian T.
Publication type:
Article
Butyrate Supplementation Exacerbates Myocardial and Immune Cell Mitochondrial Dysfunction in a Rat Model of Faecal Peritonitis.
Published in:
Life (2075-1729), 2022, v. 12, n. 12, p. 2034, doi. 10.3390/life12122034
By:
- Peters, Vera B. M.;
- Arulkumaran, Nishkantha;
- Melis, Miranda J.;
- Gaupp, Charlotte;
- Roger, Thierry;
- Shankar-Hari, Manu;
- Singer, Mervyn
Publication type:
Article
Impact of ghrelin on body composition and muscle function in a long-term rodent model of critical illness.
Published in:
PLoS ONE, 2017, v. 12, n. 8, p. 1, doi. 10.1371/journal.pone.0182659
By:
- Hill, Neil E.;
- Murphy, Kevin G.;
- Saeed, Saima;
- Phadke, Rahul;
- Chambers, Darren;
- Wilson, Duncan R.;
- Brett, Stephen J.;
- Singer, Mervyn
Publication type:
Article
The immunomodulating activity of trimodulin (polyvalent IgM, IgA, IgG solution): a post hoc analysis of the phase II CIGMA trial.
Published in:
Critical Care, 2023, v. 27, n. 1, p. 1, doi. 10.1186/s13054-023-04719-9
By:
- Singer, Mervyn;
- Torres, Antoni;
- Heinz, Corina C.;
- Weißmüller, Sabrina;
- Staus, Alexander;
- Kistner, Steffen;
- Jakubczyk, Ksenia;
- Häder, Thomas;
- Langohr, Patrick;
- Wartenberg-Demand, Andrea;
- Schüttrumpf, Jörg;
- Vincent, Jean-Louis;
- Welte, Tobias
Publication type:
Article
Real-world inter-observer variability of the sequential organ failure assessment (SOFA) score in intensive care medicine: the time has come for an update: authors' reply.
Published in:
2023
By:
- Moreno, Rui;
- Rhodes, Andrew;
- Singer, Mervyn;
- Vincent, Jean-Louis
Publication type:
Letter
The Sequential Organ Failure Assessment (SOFA) Score: has the time come for an update?
Published in:
Critical Care, 2023, v. 27, p. 1, doi. 10.1186/s13054-022-04290-9
By:
- Moreno, Rui;
- Rhodes, Andrew;
- Piquilloud, Lise;
- Hernandez, Glenn;
- Takala, Jukka;
- Gershengorn, Hayley B.;
- Tavares, Miguel;
- Coopersmith, Craig M.;
- Myatra, Sheila N.;
- Singer, Mervyn;
- Rezende, Ederlon;
- Prescott, Hallie C.;
- Soares, Márcio;
- Timsit, Jean-François;
- de Lange, Dylan W.;
- Jung, Christian;
- De Waele, Jan J.;
- Martin, Greg S.;
- Summers, Charlotte;
- Azoulay, Elie
Publication type:
Article
The Sequential Organ Failure Assessment (SOFA) Score: has the time come for an update?
Published in:
Critical Care, 2023, p. 1, doi. 10.1186/s13054-022-04290-9
By:
- Moreno, Rui;
- Rhodes, Andrew;
- Piquilloud, Lise;
- Hernandez, Glenn;
- Takala, Jukka;
- Gershengorn, Hayley B.;
- Tavares, Miguel;
- Coopersmith, Craig M.;
- Myatra, Sheila N.;
- Singer, Mervyn;
- Rezende, Ederlon;
- Prescott, Hallie C.;
- Soares, Márcio;
- Timsit, Jean-François;
- de Lange, Dylan W.;
- Jung, Christian;
- De Waele, Jan J.;
- Martin, Greg S.;
- Summers, Charlotte;
- Azoulay, Elie
Publication type:
Article
Stress response during early sedation with dexmedetomidine compared with usual-care in ventilated critically ill patients.
Published in:
2022
By:
- Moore, John P. R.;
- Shehabi, Yahya;
- Reade, Michael C.;
- Bailey, Michael;
- Fraser, John F.;
- Murray, Lauren;
- Anstey, Christopher;
- Singer, Mervyn
Publication type:
journal article
Comparison of renal replacement therapy and renal recovery before and during the COVID-19 pandemic: a single center observational study.
Published in:
Minerva Anestesiologica, 2021, v. 87, n. 11, p. 1209, doi. 10.23736/S0375-9393.21.15595-6
By:
- RYAN, Rebecca;
- TAYLOR, Isabel;
- LAING, Chris;
- SINGER, Mervyn;
- GONDONGWE, Dereck;
- MACCALLUM, Niall;
- ARULKUMARAN, Nishkantha
Publication type:
Article
Non-specialist therapeutic strategies in acute respiratory distress syndrome.
Published in:
Minerva Anestesiologica, 2021, v. 87, n. 7, p. 803, doi. 10.23736/S0375-9393.21.15254-X
By:
- LONGOBARDO, Alessia;
- SNOW, Timothy A.;
- TAM, Karen;
- SINGER, Mervyn;
- BELLINGAN, Geoff;
- ARULKUMARAN, Nishkantha
Publication type:
Article
Effect of dexamethasone in patients with ARDS and COVID-19 (REMED trial)-study protocol for a prospective, multi-centre, open-label, parallel-group, randomized controlled trial.
Published in:
2022
By:
- Maláska, Jan;
- Stašek, Jan;
- Duška, František;
- Balík, Martin;
- Máca, Jan;
- Hruda, Jan;
- Vymazal, Tomáš;
- Klementová, Olga;
- Zatloukal, Jan;
- Gabrhelík, Tomáš;
- Novotný, Pavel;
- Demlová, Regina;
- Kubátová, Jana;
- Vinklerová, Jana;
- Svobodník, Adam;
- Kratochvíl, Milan;
- Klučka, Jozef;
- Gál, Roman;
- Singer, Mervyn;
- REMED Study Group
Publication type:
journal article
Effect of dexamethasone in patients with ARDS and COVID-19 - prospective, multi-centre, open-label, parallel-group, randomised controlled trial (REMED trial): A structured summary of a study protocol for a randomised controlled trial.
Published in:
2021
By:
- Maláska, Jan;
- Stašek, Jan;
- Duška, František;
- Balík, Martin;
- Máca, Jan;
- Hruda, Jan;
- Vymazal, Tomáš;
- Klementová, Olga;
- Zatloukal, Jan;
- Gabrhelík, Tomáš;
- Novotný, Pavel;
- Demlová, Regina;
- Kubátová, Jana;
- Vinklerová, Jana;
- Svobodník, Adam;
- Kratochvíl, Milan;
- Klučka, Jozef;
- Gál, Roman;
- Singer, Mervyn;
- on behalf of the REMED Study Group
Publication type:
letter
Hypothermia protects brain mitochondrial function from hypoxemia in a murine model of sepsis.
Published in:
Journal of Cerebral Blood Flow & Metabolism, 2016, v. 36, n. 11, p. 1955, doi. 10.1177/0271678X15606457
By:
- Chisholm, Kim I.;
- Ida, Keila K.;
- Davies, Andrew L.;
- Tachtsidis, Ilias;
- Papkovsky, Dmitri B.;
- Dyson, Alex Dyson;
- Singer, Mervyn;
- Duchen, Michael R.;
- Smith, Kenneth J.
Publication type:
Article
Corticosteroids in adult respiratory distress syndrome – an inconvenient truth?
Published in:
International Journal of Pharmacy Practice, 2021, v. 29, n. 6, p. 642, doi. 10.1093/ijpp/riab053
By:
- Shulman, Rob;
- Montanari, Cecilia;
- Pinheiro, Inês;
- Longobardo, Alessia;
- Benhalm, Suzanne;
- Polhill, Sara;
- Singer, Mervyn;
- Bellingan, Geoff;
- Arulkumaran, Nishkantha
Publication type:
Article
Pharmacological inhibition of DDAH1 improves survival, haemodynamics and organ function in experimental septic shock.
Published in:
Biochemical Journal, 2014, v. 460, n. 2, p. 309, doi. 10.1042/BJ20131666
By:
- WANG, Zhen;
- LAMBDEN, Simon;
- TAYLOR, Valerie;
- SUJKOVIC, Elizabeth;
- NANDI, Manasi;
- TOMLINSON, James;
- DYSON, Alex;
- MCDONALD, Neil;
- CADDICK, Stephen;
- SINGER, Mervyn;
- LEIPER, James
Publication type:
Article
Beta-blockers in sepsis.
Published in:
Qatar Medical Journal, 2019, v. 2019, n. 2, p. 1, doi. 10.5339/qmj.2019.qccc.42
By:
- Singer, Mervyn
Publication type:
Article
Biomarkers for sepsis - past, present and future.
Published in:
Qatar Medical Journal, 2019, v. 2019, n. 2, p. 1, doi. 10.5339/qmj.2019.qccc.8
By:
- Singer, Mervyn
Publication type:
Article
The Importance of Shifting Sepsis Quality Measures From Processes to Outcomes.
Published in:
JAMA: Journal of the American Medical Association, 2023, v. 329, n. 7, p. 535, doi. 10.1001/jama.2023.0340
By:
- Klompas, Michael;
- Rhee, Chanu;
- Singer, Mervyn
Publication type:
Article
Prevalence and Outcomes of Infection Among Patients in Intensive Care Units in 2017.
Published in:
JAMA: Journal of the American Medical Association, 2020, v. 323, n. 15, p. 1478, doi. 10.1001/jama.2020.2717
By:
- Vincent, Jean-Louis;
- Sakr, Yasser;
- Singer, Mervyn;
- Martin-Loeches, Ignacio;
- Machado, Flavia R.;
- Marshall, John C.;
- Finfer, Simon;
- Pelosi, Paolo;
- Brazzi, Luca;
- Aditianingsih, Dita;
- Timsit, Jean-François;
- Du, Bin;
- Wittebole, Xavier;
- Máca, Jan;
- Kannan, Santhana;
- Gorordo-Delsol, Luis A.;
- De Waele, Jan J.;
- Mehta, Yatin;
- Bonten, Marc J. M.;
- Khanna, Ashish K.
Publication type:
Article
Prevalence and Outcomes of Infection Among Patients in Intensive Care Units in 2017.
Published in:
2020
By:
- Vincent, Jean-Louis;
- Sakr, Yasser;
- Singer, Mervyn;
- Martin-Loeches, Ignacio;
- Machado, Flavia R;
- Marshall, John C;
- Finfer, Simon;
- Pelosi, Paolo;
- Brazzi, Luca;
- Aditianingsih, Dita;
- Timsit, Jean-François;
- Du, Bin;
- Wittebole, Xavier;
- Máca, Jan;
- Kannan, Santhana;
- Gorordo-Delsol, Luis A;
- De Waele, Jan J;
- Mehta, Yatin;
- Bonten, Marc J M;
- Khanna, Ashish K
Publication type:
journal article
Antibiotics for Sepsis-Finding the Equilibrium.
Published in:
2018
By:
- Klompas, Michael;
- Calandra, Thierry;
- Singer, Mervyn
Publication type:
journal article
Critical illness and flat batteries.
Published in:
2017
By:
- Singer, Mervyn
Publication type:
journal article
Seven unconfirmed ideas to improve future ICU practice.
Published in:
2017
By:
- Marini, John J.;
- De Backer, Daniel;
- Ince, Can;
- Singer, Mervyn;
- Van Haren, Frank;
- Westphal, Martin;
- Wischmeyer, Paul
Publication type:
journal article
Translational evidence for two distinct patterns of neuroaxonal injury in sepsis: a longitudinal, prospective translational study.
Published in:
2017
By:
- Ehler, Johannes;
- Barrett, Lucinda K.;
- Taylor, Valerie;
- Groves, Michael;
- Scaravilli, Francesco;
- Wittstock, Matthias;
- Kolbaske, Stephan;
- Grossmann, Annette;
- Henschel, Jörg;
- Gloger, Martin;
- Sharshar, Tarek;
- Chretien, Fabrice;
- Gray, Francoise;
- Nöldge-Schomburg, Gabriele;
- Singer, Mervyn;
- Sauer, Martin;
- Petzold, Axel
Publication type:
journal article
Decatecholaminisation during sepsis.
Published in:
Critical Care, 2016, v. 20, p. 1, doi. 10.1186/s13054-016-1488-x
By:
- Rudiger, Alain;
- Singer, Mervyn
Publication type:
Article
Near-infrared spectroscopy for assessing tissue oxygenation and microvascular reactivity in critically ill patients: a prospective observational study.
Published in:
Critical Care, 2016, v. 20, p. 1, doi. 10.1186/s13054-016-1500-5
By:
- Donati, Abele;
- Damiani, Elisa;
- Domizi, Roberta;
- Scorcella, Claudia;
- Carsetti, Andrea;
- Tondi, Stefania;
- Monaldi, Valentina;
- Adrario, Erica;
- Romano, Rocco;
- Pelaia, Paolo;
- Singer, Mervyn
Publication type:
Article
Feasibility of Noninvasive Positive Pressure Ventilation in the Treatment of Oxygen-Dependent COVID-19 Patients in Peru.
Published in:
American Journal of Tropical Medicine & Hygiene, 2021, v. 105, n. 3, p. 727, doi. 10.4269/ajtmh.21-0363
By:
- Cárcamo, Paloma M.;
- Laca-Barrera, Manuel;
- Cabanillas-Silva, Diana;
- Málaga-Rodríguez, Germán;
- Mallma-Salazar, Patricia;
- Moore, David;
- Shipley, Rebecca;
- Singer, Mervyn;
- Garcia, Patricia J.
Publication type:
Article
One-Year Survival and Hospital-free Days in Critical Illness After Viral Pneumonia.
Published in:
American Journal of Respiratory & Critical Care Medicine, 2024, v. 209, n. 8, p. 1019, doi. 10.1164/rccm.202310-1771LE
By:
- Atramont, Alice;
- Martin, Guillaume L.;
- Singer, Mervyn;
- Tajahmady, Ayden;
- Agamaliyev, Emin;
- Harhay, Michael O.;
- Leone, Marc;
- Legrand, Matthieu
Publication type:
Article
Less Haste, More Speed, More Science: Lessons to be Learned from COVID-19 Studies.
Published in:
American Journal of Respiratory & Critical Care Medicine, 2022, v. 205, n. 11, p. 1258, doi. 10.1164/rccm.202203-0617ED
By:
- Singer, Mervyn
Publication type:
Article
The Many Roles of Cholesterol in Sepsis: A Review.
Published in:
2022
By:
- Hofmaenner, Daniel A.;
- Kleyman, Anna;
- Press, Adrian;
- Bauer, Michael;
- Singer, Mervyn
Publication type:
journal article
Immunomodulators in COVID-19: Two Sides to Every Coin.
Published in:
2020
By:
- Snow, Timothy A. C.;
- Singer, Mervyn;
- Arulkumaran, Nishkantha
Publication type:
letter
Reply to Tasker and to Lellouche and L'Her.
Published in:
2020
By:
- Palmer, Edward;
- Martin, Daniel;
- Singer, Mervyn;
- Harris, Steve
Publication type:
letter
The Association between Supraphysiologic Arterial Oxygen Levels and Mortality in Critically Ill Patients. A Multicenter Observational Cohort Study.
Published in:
2019
By:
- Palmer, Edward;
- Post, Benjamin;
- Klapaukh, Roman;
- Marra, Giampiero;
- MacCallum, Niall S.;
- Brealey, David;
- Ercole, Ari;
- Jones, Andrew;
- Ashworth, Simon;
- Watkinson, Peter;
- Beale, Richard;
- Brett, Stephen J.;
- Young, J. Duncan;
- Black, Claire;
- Rashan, Aasiyah;
- Martin, Daniel;
- Singer, Mervyn;
- Harris, Steve
Publication type:
journal article
Deconstructing Hyperlactatemia in Sepsis Using Central Venous Oxygen Saturation and Base Deficit.
Published in:
2019
By:
- Semler, Matthew W.;
- Singer, Mervyn;
- Esquinas, Antonio M.
Publication type:
journal article
Do antibiotics cause mitochondrial and immune cell dysfunction? A literature review.
Published in:
2022
By:
- Miller, Muska;
- Singer, Mervyn
Publication type:
journal article
Immunophenotyping patients with sepsis and underlying haematological malignancy reveals defects in monocyte and lymphocyte function.
Published in:
Intensive Care Medicine Experimental, 2024, v. 12, n. 1, p. 1, doi. 10.1186/s40635-023-00578-4
By:
- Snow, Timothy Arthur Chandos;
- Serisier, Aimee;
- Brealey, David;
- Singer, Mervyn;
- Arulkumaran, Nishkantha;
- University College London Hospitals Critical Care Research Team;
- Saleem, Naveed;
- Cesar, Antonio;
- Waller, Alessia V.;
- Ryckaert, Francis;
- Smyth, Deborah;
- Bercades, Georgia;
- Hass, Ingrid;
- Zapata Martinez, Alexandra;
- Gallagher, Laura;
- Martir, Gladys
Publication type:
Article
TREM-1 promotes survival during septic shock in mice.
Published in:
European Journal of Immunology, 2007, v. 37, n. 2, p. 456, doi. 10.1002/eji.200636387
By:
- Gibot, Sébastien;
- Massin, Frederic;
- Marcou, Markella;
- Taylor, Valerie;
- Stidwill, Ray;
- Wilson, Peter;
- Singer, Mervyn;
- Bellingan, Geoff
Publication type:
Article
Judging quality of current septic shock definitions and criteria.
Published in:
2015
By:
- Shankar-Hari, Manu;
- Bertolini, Guido;
- Brunkhorst, Frank M.;
- Bellomo, Rinaldo;
- Annane, Djillali;
- Deutschman, Clifford S.;
- Singer, Mervyn
Publication type:
journal article
Arterial hyperoxia and mortality in critically ill patients: a systematic review and meta-analysis.
Published in:
Critical Care, 2014, v. 18, n. 6, p. 530, doi. 10.1186/s13054-014-0711-x
By:
- Damiani, Elisa;
- Adrario, Erica;
- Girardis, Massimo;
- Romano, Rocco;
- Pelaia, Paolo;
- Singer, Mervyn;
- Donati, Abele
Publication type:
Article
Arterial hyperoxia and mortality in critically ill patients: a systematic review and meta-analysis.
Published in:
2014
By:
- Damiani, Elisa;
- Adrario, Erica;
- Girardis, Massimo;
- Romano, Rocco;
- Pelaia, Paolo;
- Singer, Mervyn;
- Donati, Abele
Publication type:
journal article
Inflammation biomarkers and delirium in critically ill patients.
Published in:
Critical Care, 2014, v. 18, n. 3, p. 1, doi. 10.1186/cc13887
By:
- Ritter, Cristiane;
- Tomasi, Cristiane D.;
- Dal-Pizzol, Felipe;
- Pinto, Bernardo Bollen;
- Dyson, Alex;
- de Miranda, Aline S.;
- Comim, Clarissa M.;
- Soares, Márcio;
- Teixeira, Antonio L.;
- Quevedo, João;
- Singer, Mervyn
Publication type:
Article
Inflammation biomarkers and delirium in critically ill patients.
Published in:
2014
By:
- Ritter, Cristiane;
- Tomasi, Cristiane D;
- Dal-Pizzol, Felipe;
- Pinto, Bernardo;
- Dyson, Alex;
- de Miranda, Aline S;
- Comim, Clarissa M;
- Soares, Márcio;
- Teixeira, Antonio L;
- Quevedo, Joao;
- Singer, Mervyn;
- Pinto, Bernardo Bollen;
- Quevedo, João
Publication type:
journal article
Changes in dental plaque following hospitalisation in a critical care unit: an observational study.
Published in:
Critical Care, 2013, v. 17, n. 5, p. R189, doi. 10.1186/cc12878
By:
- Sachdev, Mishal;
- Ready, Derren;
- Brealey, David;
- Jung Hyun Ryu;
- Bercades, Georgia;
- Nagle, Janette;
- Borja-Boluda, Susana;
- Agudo, Elisa;
- Petrie, Aviva;
- Suvan, Jean;
- Donos, Nikos;
- Singer, Mervyn;
- Needleman, Ian
Publication type:
Article
Changes in dental plaque following hospitalisation in a critical care unit: an observational study.
Published in:
2013
By:
- Sachdev, Mishal;
- Ready, Derren;
- Brealey, David;
- Ryu, Jung;
- Bercades, Georgia;
- Nagle, Janette;
- Borja-Boluda, Susana;
- Agudo, Elisa;
- Petrie, Aviva;
- Suvan, Jean;
- Donos, Nikos;
- Singer, Mervyn;
- Needleman, Ian
Publication type:
journal article
Our favorite unproven ideas for future critical care.
Published in:
Critical Care, 2013, v. 17, p. 1, doi. 10.1186/cc11507
By:
- Marini, John J.;
- Vincent, Jean-Louis;
- Wischmeyer, Paul;
- Singer, Mervyn;
- Gattinoni, Luciano;
- Ince, Can;
- Gan, Tong Joo
Publication type:
Article
Advancing critical care: time to kiss the right frog.
Published in:
Critical Care, 2013, v. 17, p. 1, doi. 10.1186/cc11501
By:
- Singer, Mervyn
Publication type:
Article
Advancing critical care: time to kiss the right frog.
Published in:
2013
By:
- Singer, Mervyn
Publication type:
journal article
Our favorite unproven ideas for future critical care.
Published in:
2013
By:
- Marini, John J;
- Vincent, Jean-Louis;
- Wischmeyer, Paul;
- Singer, Mervyn;
- Gattinoni, Luciano;
- Ince, Can;
- Gan, Tong Joo
Publication type:
journal article

Found: 210