The effects of the pulsed magnetic field on sepsis-induced liver tissue injury in rats.

Gevrek, Fikret; Yelli, Serkan; Gürgül, Serkan

Sepsis is the host's response to infection and can lead to severe and life-threatening cases. We aimed to investigate the effects of pulsed magnetic field (PMF) on septic liver tissue injury. A total of 28 adult Wistar albino rats were divided equally into four study groups: Sham, PMF-1, PMF-2, and Sepsis, with seven rats in each. Sepsis was performed using the CLP method. PMF-1 and PMF-2 were exposed to 7.5 Hz and 15 Hz PMF, respectively, for 24 hours. After having their livers removed, liver tissues were analysed using histological techniques. We observed remarkable healing in PMF groups. Apoptotic cells decreased in the PMF-treated groups compared with the Sepsis group (p < 0.05). Immune expressions of Acas-3, Bax, and HIF-1 increased in the Sepsis group, while Bcl-2 expression decreased (p < 0.05). The results imply that PMF application has anti-apoptotic, antiinflammatory, and therapeutic effects on septic liver tissue injury.

SEPSIS; MAGNETIC field effects; SOFT tissue injuries; LIVER injuries; HISTOLOGICAL techniques; LABORATORY rats

General Physiology & Biophysics, 2023, Vol 42, Issue 6, p539

0231-5882

Academic Journal

10.4149/gpb_2023026