Urinary tract infection in the context of mini-invasive procedures after kidney transplantation.

KLEINOVA, Patricia; BELIANCINOVA, Monika; VNUCAK, Matej; GRANAK, Karol; MOKAN, Marian; DEDINSKA, Ivana

INTRODUCTION: The use of antibiotic prophylaxis in invasive procedures is generally accepted and highly recommended. The question is the need to apply antibiotic prophylaxis even in the case of mini-invasive procedures in the post-transplantation period. The aim of the study was to determine the occurrence of infectious complications during mini-invasive procedures (pig-tail extraction, protocol biopsy) without the use of antibiotic (ATB) prophylaxis. The secondary aim was to identify risk factors for a positive urine culture finding at the time of mini-invasive procedures. MATERIAL: This is a prospective monocentric study in which patients after kidney transplantation at Transplantation centrum in Martin were included (n = 68). We investigated the incidence of positive urine findings at the time of pig-tail extraction (6 weeks after transplantation) and at the time of protocol biopsy (3 months after transplantation) with comparison within the group with and without ATB prophylaxis. RESULTS: Patients in group without ATB prophylaxis had a significantly higher tacrolimus value at the time of pig-tail extraction (p = 0.0274) and a significantly higher dose of mycophenolic acid at the time of protocol biopsy (p = 0.0429). We did not confirm significant difference in occurrence of positive urine findings at the time of pig-tail extraction or at the time of protocol biopsy. We completed a univariate logistic regression in order to identify a potential risk predictor for positive urine findings at the time of pig-tail extraction and protocol biopsy. None of the monitored parameters, including ATB prophylaxis, was confirmed as risk or protective factor. CONCLUSION: The use of antibiotic prophylaxis during mini-invasive procedures (pig-tail extraction, protocol biopsy) in the posttransplantation period had no effect on positive culture findings at our department. Based on our analysis, we therefore do not use antibiotic prophylaxis in the case of these procedures at our centre (Tab. 3, Fig. 6, Ref. 23).

ANTIBIOTIC prophylaxis; KIDNEY transplantation; DENTAL extraction; URINARY tract infections; MYCOPHENOLIC acid; LOGISTIC regression analysis

Bratislava Medical Journal / Bratislavské Lekárske Listy, 2023, Vol 124, Issue 10, p727

0006-9248

Academic Journal

10.4149/BLL_2023_110