The impact of different induction immunosuppression protocol on patient survival, graft survival and acute graft rejection after kidney transplantation.

VNUCAK, Matej; GRANAK, Karol; BELIANCINOVA, Monika; GALA, Igor; CHRAPEKOVA, Michaela; KOVACOVA, Andrea; BENA, Luboslav; ZILINSKA, Zuzana; DEDINSKA, Ivana

OBJECTIVES: The aim of the study was to stratify the immunological risk based on the presence of risk factors using different induction immunosuppressive protocols. BACKGROUND: The path to successful kidney transplantation reflects the accuracy of immunological risk assessment and choice of correct induction and maintenance of immunosuppression to avoid acute kidney rejection. METHODS: We performed a multicentre prospective analysis consisting of patients after kidney transplantation with a 12-month follow-up. RESULTS: In total, 152 kidney transplant recipients were included, of whom 100 were males (66.4 %). We divided patients according to the induction immunosuppression as follows: no induction (n = 19), induction with basiliximab (n = 60), and induction with ATG cumulative dose 3.5 mg/kg (n = 42) and 6 mg/kg (n = 31). In our study, we demonstrated a shorter survival of patients without induction immunosuppression. In the basiliximab group, the duration of dialysis ≥ 3 years (p = 0.0191), cold ischaemia time > 1,020 minutes or expected delayed graft function (p < 0.0001) are independent risk factors for graft loss (p = 0.0097). CONCLUSIONS: Risk of no induction immunosuppression significantly exceeds the risks associated with its administration and is desirable even in patients at low immunological risk. Induction immunosuppression should be tailored individually and thus differ from patient to patient (Tab. 6, Fig. 1, Ref. 15). Text in PDF www.elis.sk

KIDNEY transplantation; GRAFT rejection; GRAFT survival; OVERALL survival; IMMUNOSUPPRESSION

Bratislava Medical Journal / Bratislavské Lekárske Listy, 2022, Vol 123, Issue 10, p730

0006-9248

Academic Journal

10.4149/BLL_2022_117