Age and sex disparity in infectious complications after kidney transplantation.

Matej, VNUCAK; Karol, GRANAK; Monika, BELIANCINOVA; Juraj, MIKLUSICA; Ivana, DEDINSKA

OBJECTIVES: The aim of our analysis was to find whether there are sex and age differences in the incidence of single and repeat infection after kidney transplantation (KT). BACKGROUND: Potent immunosuppression lowers the incidence of acute graft rejection but increases the risk of post-transplant infections. Older adults and females are at high risk of infections leading to poor outcome after KT. MATERIALS: Our analysis consisted of 66 males and 34 females after KT, average age 47.5±12.6 years. RESULTS: Female gender was a RF for the incidence of infection in general (p=0.0054), recurrent (p=0.0239), bacterial (p=0.0125) and mycotic infection (p=0.0103), recurrent bacterial infection (p=0.0258) 1st month after KT, RF for the incidence of infection in general (p=0.0218), bacterial (p=0.0186), mycotic (p=0.0318), recurrent (p=0.0216), recurrent bacterial infection (p=0.0368) from 1st to 6th month after KT and RF for the incidence of bacterial (p=0.0144), single (p=0.0355), recurrent (p=0.0007) and single bacterial infection (p=0.0309) 6 months after KT. Age >60 years was not found as a RF for the incidence of single, repeat infection regarding its aetiology. CONCLUSION: We found significant sex differences in the incidence of single and repeat infections in different time intervals after KT (Tab. 4, Fig. 3, Ref. 31). Text in PDF www.elis.sk.

KIDNEY transplant complications; MYCOSES; GRAFT rejection; AGE differences; KIDNEY transplantation; BACTERIAL diseases; IMMUNOSUPPRESSION

Bratislava Medical Journal / Bratislavské Lekárske Listy, 2022, Vol 123, Issue 7, p463

0006-9248

Academic Journal

10.4149/BLL_2022_074