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- Title
Hybrid imaging in dementia: A semi-quantitative (<sup>18</sup>F)-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging approach in clinical practice.
- Authors
Franceschi, Ana; Naser-Tavakolian, Kiyon; Clifton, Michael; Ahmed, Osama; Stoffers, Katarina; Bangiyev, Lev; Cruciata, Giuseppe; Clouston, Sean; Franceschi, Dinko
- Abstract
Neurodegenerative disorders may demonstrate typical lobar and regional patterns of volume loss with corresponding decreased glucose metabolism. In this retrospective study, we correlated semi-quantitative volumetric changes utilizing NeuroQuant morphometric analysis with decreased fluorodeoxyglucose (FDG) uptake age-matched calculated z-scores utilizing18F-FDG positron emission tomography/magnetic resonance imaging (PET/MRI). Eighty-nine patients (mean age 71.4) with clinical findings suggestive of various subtypes of dementia underwent PET/MR brain imaging. Cases were categorized as follows: Alzheimer's dementia (AD), frontotemporal lobar degeneration (FTLD), dementia with Lewy bodies (DLB), and corticobasal degeneration (CBD). NeuroQuant software provided semi-quantitative assessment of lobar-specific patterns of volume loss compared to age-matched controls. MIMneuro software provided semi-quantitative FDG uptake data, with metabolic z-scores generated in comparison to age-matched controls. Volumetric and metabolic data were then correlated for statistical significance. In 29 AD cases, Pearson correlation coefficient between z-score and lobar volume was 0.3 (P = 0.120) and 0.38 (P < 0.05), for parietal and temporal lobes, respectively. In 34 FTLD cases, it was 0.35 (P = 0.051) and 0.02 (P = 0.916), for frontal and temporal lobes, respectively. In 14 DLB cases, it was 0.42 (P = 0.130), 0.5 (P = 0.067), and 0.22 (P = 0.447) for the occipital lobes, middle occipital gyrus, and parietal lobes, respectively. In 12 CBD cases, it was 0.58 (P < 0.05) for the superior parietal lobule. Semi-quantitative (F18)-FDG PET/MRI analysis demonstrated a positive relationship between volumetric loss and hypometabolism within certain lobar-specific regions, depending on neurodegenerative disorder subtype. Our findings may add diagnostic confidence in the accurate imaging diagnosis of neurodegenerative disease.
- Subjects
MAGNETIC resonance imaging; POSITRON emission tomography; LEWY body dementia; DEMENTIA; PARIETAL lobe; FRONTOTEMPORAL lobar degeneration
- Publication
World Journal of Nuclear Medicine, 2021, Vol 20, Issue 1, p23
- ISSN
1450-1147
- Publication type
Academic Journal
- DOI
10.4103/wjnm.WJNM_27_20