Successful treatment of epidermal growth factor receptor exon 19 deletion non-small cell lung cancer with almonertinib after osimertinib-induced interstitial lung disease: A case report.

Li, Zhichao; Wang, Gang; Xue, Guoliang; Wang, Nan; Hu, Yanting; Cao, Pikun; Cai, Hongchao; Wei, Zhigang; Ye, Xin

Osimertinib, a third-generation epidermal growth factor receptor (EGFR)–tyrosine kinase inhibitor (TKI), has revolutionized one of the standard most efficient treatments for EGFR mutation-positive non-small cell lung cancer (NSCLC). Osimertinib, a third-generation EGFR–TKI, is currently one of most efficient treatments in clinical practice. However, it has a potentially fatal side effect: interstitial lung disease (ILD). When severe ILD occurs, a drug substitution is often required, and there is a rising concern about which drug to choose to inhibit the progression of NSCLC and avoid aggravating while alleviating ILD. Herein, we report an NSCLC case with osimertinib-induced ILD successfully rechallenged by almonertinib. In addition, we conducted a literature review on the clinical efficacy and adverse effects of almonertinib, hoping to provide insight into NSCLC treatment.

INTERSTITIAL lung diseases; EPIDERMAL growth factor receptors; NON-small-cell lung carcinoma; KINASE inhibitors; OSIMERTINIB

Journal of Cancer Research & Therapeutics, 2024, Vol 20, Issue 7, p2148

0973-1482

Academic Journal

10.4103/jcrt.jcrt_2235_24