Title: Successful treatment of Rosai-Dorfman disease using photoimmunotherapy.
Authors: Li, Meng; Shi, Lei; Luo, Min; Chen, Jia; Wang, Bo; Zhang, Fuhe; Keyal, Uma; Bhatta, Anil Kumar; Chen, Wei R; Wang, Xiuli
Abstract: Rosai-Dorfman disease is difficult to cure. In situ photoimmunotherapy combines local photothermal therapy with immunoadjuvant. In the present case report, a 39-year-old Chinese man with Rosai-Dorfman disease lesions below the left nostril and left preauricular region was treated with in situ photoimmunotherapy. The patient was treated with daily application of topical imiquimod (5%) and laser irradiations every 2 weeks for 8 weeks. After three cycles of treatment, the lesions improved markedly without adverse effects. Our results showed that in situ photoimmunotherapy can be used as an effective treatment for Rosai-Dorfman disease.
Subjects: NON-langerhans-cell histiocytosis; IMMUNOTHERAPY; PHOTOTHERAPY; TREATMENT effectiveness; THERAPEUTICS
Publication: Indian Journal of Dermatology, Venereology & Leprology, 2017, Vol 83, Issue 3, p332
ISSN: 0378-6323
Publication type: Academic Journal
DOI: 10.4103/ijdvl.IJDVL_356_16

Successful treatment of Rosai-Dorfman disease using photoimmunotherapy.

Li, Meng; Shi, Lei; Luo, Min; Chen, Jia; Wang, Bo; Zhang, Fuhe; Keyal, Uma; Bhatta, Anil Kumar; Chen, Wei R; Wang, Xiuli