Works matching DE "DRUG target"

Results: 5000

Mir-509-3p targets SLC25A13 to regulate ferroptosis and protect retinal endothelial cells in diabetic retinopathy.

Published in:

Acta Diabetologica, 2025, v. 62, n. 6, p. 831, doi. 10.1007/s00592-024-02400-3

By:

Ren, Meiqing;
Xu, Qian;
Luan, Jie;
Ni, Yan;
Xie, Bo

Publication type:

Article

Lactate metabolism-related genes serve as potential biomarkers for predicting gastric cancer progression and immunotherapy.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02782-y

By:

Yuan, Mingjie;
Li, Xuekai;
Song, Xuanli;
Chen, Xiaowei;
Wang, Yunshan;
Han, Shuyi;
Ni, Yang;
Liu, Duanrui

Publication type:

Article

Study on DNA Damage Gene in Spermatogonial Stem Cells from Idiopathic Nonobstructive Azoospermia: A Bioinformatics Investigation Based on scRNA-seq Data.

Published in:

Cytogenetic & Genome Research, 2025, v. 165, n. 1, p. 9, doi. 10.1159/000545275

By:

Wang, Yi;
Weng, Yiming;
Wang, Yanqiu;
Xiang, Jun;
Le, Wei

Publication type:

Article

PPARγ/β/δ Agonists Can Ameliorate Dextran Sodium Sulfate–Induced Colitis and Modulate Gut Microbiota.

Published in:

Journal of Gastroenterology & Hepatology, 2025, v. 40, n. 6, p. 1536, doi. 10.1111/jgh.16929

By:

Li, Jian‐Hong;
Xu, Jing;
Hu, Jin‐Xia;
Xu, Hao‐Ming;
Guo, Xue;
Zhang, Yan;
Xu, Jing‐Kui;
Huang, Chen;
Nie, Yu‐Qiang;
Zhou, You‐Lian

Publication type:

Article

Causal Associations Between Lipids, NPC1L1, and Liver Cancer Risk: Insights From Mendelian Randomization and Bioinformatics.

Published in:

Journal of Gastroenterology & Hepatology, 2025, v. 40, n. 6, p. 1602, doi. 10.1111/jgh.16897

By:

Guo, Xiaoyan;
Wu, Lili;
Lai, Jing;
Wu, Yuankai;
Chen, Dianke

Publication type:

Article

"A REVIEW ON MICROEMULSION AND MICROSPHERE : A PROMISING OPTIMIZING TECHNIQUE FOR ADVANCED DRUG DELIVERY SYSTEM".

Published in:

Bulletin of Pure & Applied Sciences-Zoology, 2024, v. 43, p. 641

By:

Avinash, Chavan;
Kulkarni, A. S.;
Phalake, R. A.;
Sawant, Prachi;
Bade, Omkesh;
Kandurkar, Prafull;
Patil, Prajakta;
Sawant, Pramod

Publication type:

Article

UXT enhances melanoma proliferation, migration, and invasion through modulation of the P53 signaling pathway.

Published in:

Cell Division, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13008-025-00151-3

By:

Xiong, Kaifen;
Wang, Chong;
Hu, Bingqian;
Zhang, Jianglin;
Qi, Min

Publication type:

Article

Bibliometric analysis of MXRA7 gene research trajectory: trends and insights (2015–2024).

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02824-5

By:

Zhang, Huihui;
Shen, Ying;
Bai, Peijian;
Wu, Xiaorui;
Li, Ping;
Wang, Ting

Publication type:

Article

PSORIASIS - WHAT'S NEW? SHORT SYNOPSIS.

Published in:

Dermatovenerologia Journal, 2025, v. 70, n. 1, p. 33

By:

MIHALACHE, DANIELA;
MEHEDINȚI, MIHAELA-CEZARINA;
HÎNCU, MARIA-ANDRADA;
ONOFREI, ANDREEA;
CHELMU-VODĂ, CRISTINA;
GURĂU, ALINA-MIHAELA;
GAVRILIȚĂ, ELENA;
TATU, ALIN LAURENȚIU

Publication type:

Article

Unlocking Asthma Remission: Key Insights From an Expert Roundtable Discussion.

Published in:

Respirology, 2025, v. 30, n. 6, p. 466, doi. 10.1111/resp.70047

By:

Thomas, Dennis;
Lewthwaite, Hayley;
Gibson, Peter G.;
Majellano, Eleanor;
Clark, Vanessa;
Fricker, Michael;
Hamada, Yuto;
Anderson, Gary P.;
Backer, Vibeke;
Bardin, Philip;
Beasley, Richard;
Chien, Jimmy;
Farah, Claude S.;
Harrington, John;
Harvey, Erin;
Hew, Mark;
Holland, Anne E.;
Jenkins, Christine;
Katelaris, Constance H.;
Katsoulotos, Gregory

Publication type:

Article

Evaluating metabolome-wide causal effects on risk for psychiatric and neurodegenerative disorders.

Published in:

BMC Medicine, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12916-025-04129-4

By:

Gilchrist, Lachlan;
Mutz, Julian;
Hysi, Pirro;
Legido-Quigley, Cristina;
Kõks, Sulev;
Lewis, Cathryn M.;
Proitsi, Petroula

Publication type:

Article

Molecular docking of quercetin: a promising approach for the development of new anti-inflammatory and analgesic drugs.

Published in:

Natural Product Research, 2025, v. 39, n. 11, p. 3202, doi. 10.1080/14786419.2024.2333053

By:

Ettitaou, Amina;
Kabdy, Hamid;
Oubella, Khadija;
Raoui, Karima;
Oubahmane, Mehdi;
Aboufatima, Rachida;
Elyazouli, Loubna;
Garzoli, Stefania;
Chait, Abderrahman

Publication type:

Article

Radiotheranostic landscape: A review of clinical and preclinical development.

Published in:

European Journal of Nuclear Medicine & Molecular Imaging, 2025, v. 52, n. 7, p. 2685, doi. 10.1007/s00259-025-07103-7

By:

Tran, Ha H.;
Yamaguchi, Aiko;
Manning, H. Charles

Publication type:

Article

Loss of UBE3A impacts both neuronal and non-neuronal cells in human cerebral organoids.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-08262-x

By:

Estridge, R. Chris;
Yagci, Z. Begum;
Sen, Dilara;
Johnson, Tyler J.;
Kelkar, Gautami R.;
Ptacek, Travis S.;
Simon, Jeremy M.;
Keung, Albert J.

Publication type:

Article

The Alkaloid Gelsemine Reduces Aβ Peptide Toxicity by Targeting Transglutaminase Type 2 Enzyme.

Published in:

Plants (2223-7747), 2025, v. 14, n. 10, p. 1556, doi. 10.3390/plants14101556

By:

Panes-Fernández, Jessica;
Marileo, Ana M.;
Espinoza-Rubilar, Nicole;
Meza, Macarena E.;
Salgado-Martínez, Bernardita A.;
Gaete-Riquelme, Krishna;
Moraga-Cid, Gustavo;
Castro, Patricio A.;
Burgos, Carlos F.;
Fuentealba, Jorge;
Yévenes, Gonzalo E.

Publication type:

Article

Genome-Wide Analysis of Zm4CL Genes Identifies Zm4CL8 Regulating Drought and Salt Tolerance in Maize.

Published in:

Agronomy, 2025, v. 15, n. 5, p. 1100, doi. 10.3390/agronomy15051100

By:

Zhang, Ze;
Wang, Yanbin;
Li, Rong

Publication type:

Article

Shed Syndecan-4 and Its Possible Roles in Osteoarthritis.

Published in:

Biomedicines, 2025, v. 13, n. 5, p. 1037, doi. 10.3390/biomedicines13051037

By:

He, Kangping;
Ren, Haozhe;
Chen, Xiaohua;
He, Feng;
Zhang, Yueying;
Zhang, Hongyun;
Li, Feifei;
Yu, Shibin

Publication type:

Article

Transcriptomic Profiling Uncovers Molecular Basis for Sugar and Acid Metabolism in Two Pomegranate (Punica granatum) Varieties.

Published in:

Foods, 2025, v. 14, n. 10, p. 1755, doi. 10.3390/foods14101755

By:

Ke, Ding;
Zhang, Yilong;
Teng, Yingfen;
Zhao, Xueqing

Publication type:

Article

Integrating Transcriptomic and Proteomic Data: IL‐27B as a Key Protein in the Development of Septic Cardiomyopathy—A Retrospective Study.

Published in:

Immunity, Inflammation & Disease, 2025, v. 13, n. 5, p. 1, doi. 10.1002/iid3.70207

By:

Mao, Yifeng;
Chen, Qingqing;
Jiang, Yongpo;
Zhang, Xijiang;
Si, Qin;
Xu, Panpan;
Zhang, Zhongheng;
Zheng, Cheng;
Lin, Ronghai

Publication type:

Article

Molecular Targets of Oxidative Stress: Focus on Nuclear Factor Erythroid 2–Related Factor 2 Function in Leukemia and Other Cancers.

Published in:

Cells (2073-4409), 2025, v. 14, n. 10, p. 713, doi. 10.3390/cells14100713

By:

Hasan, Syed K.;
Jayakumar, Sundarraj;
Espina Barroso, Eliezer;
Jha, Anup;
Catalano, Gianfranco;
Sandur, Santosh K.;
Noguera, Nelida I.

Publication type:

Article

Nicotinamide N-Methyltransferase (NNMT) and Liver Cancer: From Metabolic Networks to Therapeutic Targets.

Published in:

Biomolecules (2218-273X), 2025, v. 15, n. 5, p. 719, doi. 10.3390/biom15050719

By:

Lai, Shi-Yan;
Zhu, Xiao-Juan;
Sun, Wei-Dong;
Bi, Shuang-Zhou;
Zhang, Chen-Ying;
Liu, An;
Li, Jiang-Hua

Publication type:

Article

Post-Translational Modifications in Multiple Myeloma: Mechanisms of Drug Resistance and Therapeutic Opportunities.

Published in:

Biomolecules (2218-273X), 2025, v. 15, n. 5, p. 702, doi. 10.3390/biom15050702

By:

Hu, Shuoyang;
Xu, Jirun;
Cui, Weiyan;
Jin, Haoran;
Wang, Xiaoyu;
Maimaitiyiming, Yasen

Publication type:

Article

Celebrating Ulrik Ringborg: Multi-Omics-Based Patient Stratification for Precision Cancer Treatment.

Published in:

Biomolecules (2218-273X), 2025, v. 15, n. 5, p. 693, doi. 10.3390/biom15050693

By:

Teleanu, Maria-Veronica;
Schneider, Annika;
Ball, Claudia R.;
Leber, Mathias Felix;
Stange, Christoph;
Krieghoff-Henning, Eva;
Beck, Katja;
Heilig, Christoph E.;
Kreutzfeldt, Simon;
Kuster, Bernhard;
Lipka, Daniel B.;
Fröhling, Stefan

Publication type:

Article

Bolstering CD8 + T Cells' Antitumor Immunity: A Promising Strategy to Improve the Response to Advanced Prostate Cancer Treatment.

Published in:

Biology (2079-7737), 2025, v. 14, n. 5, p. 544, doi. 10.3390/biology14050544

By:

Dang, Beijing;
Liang, Lixin;
Li, Zhijun;
Luo, Junli;
Zhong, Shangwei

Publication type:

Article

Comparative Analysis of Cytokine Expression Profiles in Prostate Cancer Patients.

Published in:

Biology (2079-7737), 2025, v. 14, n. 5, p. 505, doi. 10.3390/biology14050505

By:

Coelho, Karoline Brito Caetano Andrade;
Wosniaki, Denise Kusma;
Pereira, Jonatas Luiz;
Luz, Murilo;
Albrecht, Letusa;
Nardin, Jeanine Marie;
Aoki, Mateus Nobrega;
Reis, Leonardo O.;
dos Reis, Rodolfo Borges;
Zanette, Dalila Lucíola

Publication type:

Article

A Computational Approach to Identify Novel Protein Targets Uncovers New Potential Mechanisms of Action of Mirtazapine S(+) and R(−) Enantiomers in Rett Syndrome.

Published in:

Journal of Neurochemistry, 2025, v. 169, n. 5, p. 1, doi. 10.1111/jnc.70093

By:

Roggero, Ottavia Maria;
Gualandi, Nicolò;
Ciraci, Viviana;
Berutto, Vittoria;
Carosati, Emanuele;
Tongiorgi, Enrico

Publication type:

Article

Astrocyte Dysfunctions in Obsessive Compulsive Disorder: Rethinking Neurobiology and Therapeutic Targets.

Published in:

Journal of Neurochemistry, 2025, v. 169, n. 5, p. 1, doi. 10.1111/jnc.70092

By:

Gonzalez, Laurine;
Bezzi, Paola

Publication type:

Article

PKG‐Mediated Phosphorylation of TOP2A Activates HDAC to Drive Photoreceptor Cell Death in rd1 Mouse Inherited Retinal Degeneration.

Published in:

Journal of Neurochemistry, 2025, v. 169, n. 5, p. 1, doi. 10.1111/jnc.70077

By:

Dong, Yujie;
Zuo, Wandong;
Li, Yan;
Feng, Xiaoxiao;
Guo, Chunming;
Chen, Maorong;
Yan, Jie;
Hou, Chunjiang;
Peng, Hua;
Hu, Zhulin;
Liu, Hai;
Paquet‐Durand, François;
Jiao, Kangwei

Publication type:

Article

Thyroid-Stimulating Hormone: An Important Target for the Prevention of Nonalcoholic Fatty Liver Disease.

Published in:

Physiological Research, 2025, v. 74, n. 2, p. 175, doi. 10.33549/physiolres.935453

By:

Zixuan WANG;
Hanyu WANG;
Hui SUN

Publication type:

Article

The impact of gliomas on the normal brain microenvironment: a pilot study.

Published in:

Journal of Histotechnology, 2025, v. 48, n. 2, p. 93, doi. 10.1080/01478885.2024.2408505

By:

Riha, Nicole;
Moore, Jacen S.;
Criswell, Sheila

Publication type:

Article

Lipids, lipid-lowering drug target genes and pancreatic cancer: a Mendelian randomization study.

Published in:

International Journal of Clinical Pharmacy, 2025, v. 47, n. 3, p. 747, doi. 10.1007/s11096-025-01866-7

By:

Zhan, Yuxuan;
Zhang, Kai;
Fan, Yiqun;
Lin, Siyi;
Wu, Jian;
Xu, Hongxia

Publication type:

Article

Genomic landscape of biliary tract cancer and corresponding targeted treatment strategies.

Published in:

International Journal of Clinical Oncology, 2025, v. 30, n. 6, p. 1069, doi. 10.1007/s10147-025-02761-x

By:

Yamada, Daisaku;
Kobayashi, Shogo;
Doki, Yuichiro;
Eguchi, Hidetoshi

Publication type:

Article

Unveiling the nexus between environmental exposures and testicular damages: revelations from autophagy and oxidative stress imbalance.

Published in:

Cell Death Discovery, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41420-025-02543-4

By:

Kong, Xiuwen;
Wang, Xinda;
Xia, Qiushi;
Hu, Qingqing;
Yu, Wenqian;
Huang, Qiuru;
Li, Jiaxin;
Wang, Chenyu;
Lin, Ziwen;
Liu, Yiheng;
Qi, Yujuan;
Tan, Xiaofang;
Zheng, Bo;
Yu, Jun

Publication type:

Article

Super Responders in Moderate-to-Severe Atopic Dermatitis Under Treatment with Dupilumab: An Explorative Real-World Study.

Published in:

Journal of Clinical Medicine, 2025, v. 14, n. 10, p. 3480, doi. 10.3390/jcm14103480

By:

Mastorino, Luca;
Mendes-Bastos, Pedro;
Cavaliere, Giovanni;
Siliquini, Niccolo;
Ortoncelli, Michela;
Quaglino, Pietro;
Ribero, Simone

Publication type:

Article

蛋白磷酸酶 2A 与肿瘤发生发展关系的研究进展.

Published in:

Journal of Jilin University (Medicine Edition), 2025, v. 51, n. 2, p. 534, doi. 10.13481/j.1671⁃587X.20250229

By:

张慧灵;
郭文秀;
孟峻

Publication type:

Article

Crystal structures of the putative endoribonuclease L‐PSP from Entamoeba histolytica.

Published in:

Acta Crystallographica: Section F, Structural Biology Communications, 2025, v. 81, n. 6, p. 226, doi. 10.1107/S2053230X25003875

By:

Ojuromi, Oladele T.;
Giwa, Abdulazeez O.;
Gardberg, Anna;
Subramanian, Sandhya;
Myler, Peter J.;
Abendroth, Jan;
Staker, Bart;
Asojo, Oluwatoyin A.

Publication type:

Article

Uncovering the mechanism of resveratrol in the treatment of asthma: a network pharmacology approach with molecular docking and experimental validation.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1596737

By:

Chunxiao, Li;
Xin, Hou;
Bowen, Liu;
Bingqing, Sun;
Mengqi, Zhou;
Shuwen, Zhang;
Jingyuan, Zhang;
Jiangtao, Lin

Publication type:

Article

Repositioning FDA-Approved Sulfonamide-Based Drugs as Potential Carbonic Anhydrase Inhibitors in Trypanosoma cruzi : Virtual Screening and In Vitro Studies.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 5, p. 669, doi. 10.3390/ph18050669

By:

Ortiz-Pérez, Eyra;
Moreno-Rodríguez, Adriana;
Delgado-Maldonado, Timoteo;
Ortega-Balleza, Jessica L.;
González-González, Alonzo;
Paz-González, Alma D.;
Vázquez, Karina;
Avalos-Navarro, Guadalupe;
Giovannuzzi, Simone;
Supuran, Claudiu T.;
Rivera, Gildardo

Publication type:

Article

The Cordyceps Genus as a Potential Source of Bioactive Compounds for Adjuvant Cancer Therapy: A Network Pharmacology Approach.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 5, p. 667, doi. 10.3390/ph18050667

By:

Gonzalez-Llerena, Jose Luis;
Treviño-Almaguer, Daniela;
Leal-Mendez, Jesus Alejandro;
Garcia-Valdez, Gael;
Balderas-Moreno, Arely Guadalupe;
Heya, Michel Stéphane;
Balderas-Renteria, Isaias;
Camacho-Corona, María del Rayo;
Espinosa-Rodriguez, Bryan Alejandro

Publication type:

Article

Exploring Therapeutic Potential of Bi-Qi Capsules in Treatment of Gout by Discovering Crucial Drug Targets.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 5, p. 618, doi. 10.3390/ph18050618

By:

Xie, Jing;
Zhang, Yu;
Ren, Rong;
Bu, Ruizhen;
Chen, Liying;
Hou, Juezhuo;
Shang, Dandan;
Liu, Yadong;
Wang, Dan;
Wang, Tao;
Zhou, Hong

Publication type:

Article

A Highly Sensitive Giant Magnetoresistive (GMR) Biosensor Based on the Magnetic Flux Concentrator Effect.

Published in:

Micromachines, 2025, v. 16, n. 5, p. 559, doi. 10.3390/mi16050559

By:

Sun, Hao;
Li, Jiao;
Zhao, Changhui;
Ren, Chunming;
Tian, Tian;
Lei, Chong;
Sun, Xuecheng

Publication type:

Article

Dysregulation of Locus-Specific Repetitive Elements in TCGA Pan-Cancers.

Published in:

Genes, 2025, v. 16, n. 5, p. 528, doi. 10.3390/genes16050528

By:

Wang, Chao;
Liang, Chun

Publication type:

Article

Identification of the immune-associated enhancer RNA SATB1-AS1 as a novel biomarker for thymic cancer prognosis.

Published in:

PLoS ONE, 2025, v. 20, n. 5, p. 1, doi. 10.1371/journal.pone.0319965

By:

Wang, Hongpeng;
Huang, Yichu;
Min, Guangtao;
Jiang, Lei

Publication type:

Article

Therapeutic role of Crateva religiosa in diabetic nephropathy: Insights into key signaling pathways.

Published in:

PLoS ONE, 2025, v. 20, n. 5, p. 1, doi. 10.1371/journal.pone.0324028

By:

Ali, Muhammad;
Irfan, Hafiz M.;
Alamgeer;
Ullah, Aman;
Abdellattif, Magda H.;
Elodemi, Mahmoud;
Zubair, Mohammad;
Khan, Ajmal;
Al-Harrasi, Ahmed

Publication type:

Article

Precision Medicine for Pediatric Glioma and NF1-Associated Tumors: The Role of Small Molecule Inhibitors.

Published in:

Current Oncology, 2025, v. 32, n. 5, p. 280, doi. 10.3390/curroncol32050280

By:

Renzi, Samuele;
Bennett, Julie;
Thacker, Nirav;
Cacciotti, Chantel

Publication type:

Article

Therapeutic and Prognostic Potential of G Protein‐Coupled Receptors in Lung Adenocarcinoma: Evidence From Transcriptome Data and In Vitro Experiments.

Published in:

Clinical Respiratory Journal, 2025, v. 19, n. 5, p. 1, doi. 10.1111/crj.70080

By:

Yang, Feiyan;
Yang, Jianye;
Yang, Guobiao;
Zhang, Ya

Publication type:

Article

Mitochondrial Calcium Uniporter (MCU)-Mediated Calcium Overload in Psychoactive Drug Neurotoxicity: From Pathogenesis to Therapeutic Targets.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4732, doi. 10.3390/ijms26104732

By:

Yang, Xinyan;
Chen, Yinyu;
Zheng, Gaolin;
Nie, Qianyun;
Zhang, Peng

Publication type:

Article

AI-Driven Drug Target Screening Platform Identified Oncogene CACNA2D1 Activated by Enhancer Infestation in Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4697, doi. 10.3390/ijms26104697

By:

Chung, Dittman Lai-Shun;
Leung, Geoffrey Ho Duen;
Liu, Songran;
Lok, Sarah Wing Yan;
Xin, Ying;
Xia, Yunfei;
Zhavoronkov, Alex;
Pun, Frank W.;
Ng, Wai-Tong;
Dai, Wei

Publication type:

Article

In Silico Approach to Design of New Multi-Targeted Inhibitors Based on Quinoline Ring with Potential Anticancer Properties.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4620, doi. 10.3390/ijms26104620

By:

Czyżnikowska, Żaneta;
Mysłek, Martyna;
Marciniak, Aleksandra;
Płaczek, Remigiusz;
Kotynia, Aleksandra;
Krzyżak, Edward

Publication type:

Article

Therapeutic Applications of Poly-miRNAs and miRNA Sponges.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4535, doi. 10.3390/ijms26104535

By:

Avendaño-Portugal, Cynthia;
Montaño-Samaniego, Mariela;
Guttman-Bazbaz, Raquel;
Bravo-Estupiñan, Diana M.;
Ibáñez-Hernández, Miguel

Publication type:

Article