A Study of Atherosclerosis in Patients with Chronic Renal Failure with Special Reference to Carotid Artery Intima Media Thickness.

Paul, Jayanta; Dasgupta, Somnath; Ghosh, Mrinal Kanti; Shaw, Kishore; Roy, Keshab Sinha; Niyogi, Syamal Mitra

Objectives: Cardiovascular disease is the leading cause of morbidity and mortality in patients with chronic renal failure (CRF). This study attempts to identify the factors responsible for atherosclerosis in CRF patients using carotid artery intima media thickness (CAIMT) as a surrogate marker of atherosclerosis. Materials and Methods: CAIMT was measured by high-resolution B-mode ultrasonography in 100 CRF patients and 50 age- and sex-matched healthy controls. Data were analyzed by software SPSS (17th version) for Windows. Results: CRF patients had a significantly higher CAIMT (1026.83 ± 17.19 micron, mean ± SE, P < 0.001) than age- and sexmatched healthy controls (722.46 ± 7.61 micron). There was inverse correlation between CAIMT and glomerular filtration rate (GFR) (P < 0.001) independent of traditional risk factors. There was also significant positive correlation between CAIMT and traditional risk factors of atherosclerosis. Ischemic heart disease (IHD) also showed positive correlation with CAIMT (P = 0.007) and inverse correlation with GFR (P = 0.005). Conclusions: There is high prevalence of atherosclerosis in CRF patients. CAIMT can be used to detect and predict future incidence of IHD in CRF patients

ATHEROSCLEROSIS risk factors; CHRONIC kidney failure; CAROTID artery; CARDIOVASCULAR diseases; GLOMERULAR filtration rate; PATIENTS

Heart Views, 2012, Vol 13, Issue 3, p91

1995-705X

Academic Journal

10.4103/1995-705X.102147