Results
Title

Hepatoprotective activity of methanolic extract of Syzygium jambos (Linn.) leaf against paracetamol intoxicated Wistar albino rats.

Authors

Thamizh Selvam, N.; Venkatakrishnan, V.; Dhamodharan, R.; Murugesan, S.; Damodar Kumar, S.

Abstract

Hepatoprotective activity of methanolic extract of Syzygium jambos (Alston) (Linn.) leaves against Paracetamol-induced hepatic damage in Wistar albino rats was observed at two different doses, 100 and 200 mg/kg body weight. The healthy control, disease control, and standard drug Silymarin-treated groups were also maintained for the comparison. The liver marker enzymes SGOT, SGPT, ALKP, Serum Bilirubin and other metabolic parameters like total cholesterol, HDL-cholesterol were evaluated in all the experimental groups. The changes in liver function parameters were significant in comparison to disease control group and the observed efficacy was comparable to standard drug. The efficacy of the extract was found to be dose dependent. The histopathology study of liver also supports the presence of hepatoprotective activity in S. jambos by showing improved cytoarchitecture of liver cells in the treated groups. The results obtained in this study indicate necessity for further research on isolation and characterization of functional molecules from the extract.

Subjects

SYZYGIUM; LIVER disease treatment; SILYMARIN; BIOMARKERS; AYURVEDIC medicine; THERAPEUTICS

Publication

AYU: An International Quarterly Journal of Research in Ayurveda, 2013, Vol 34, Issue 3, p305

ISSN

0974-8520

Publication type

Academic Journal

DOI

10.4103/0974-8520.123133