Title: Successful penile reconstruction following prior arteriovenous loop thrombosis due to undiagnosed protein‑S deficiency and exogenous testosterone.
Authors: Anoop, Parameswaran; Malmande, Vithal; Kumar, M. N. Prakash; Rao, Naveen
Abstract: Flap failure from microvascular thrombotic occlusion is a rare but significant cause for unsuccessful reconstructive surgery. We encountered thrombosis of arteriovenous loop in a patient undergoing phallus reconstruction. Further investigations revealed underlying previously asymptomatic hypercoagulable state due to protein‑S deficiency in addition to long‑term exogenous testosterone administration. Role of thrombophilia testing, thrombogenic potential of testosterone and the need for therapeutic perioperative anti‑coagulation in such situations are described here.
Subjects: GENDER affirmation surgery; PENIS surgery; TESTOSTERONE; THROMBOSIS; ARTERIAL occlusions; SURGICAL complications; SURGICAL flaps; PROTEIN S deficiency; THERAPEUTICS
Publication: Indian Journal of Plastic Surgery, 2016, Vol 49, Issue 2, p268
ISSN: 0970-0358
Publication type: Academic Journal
DOI: 10.4103/0970-0358.191307

Successful penile reconstruction following prior arteriovenous loop thrombosis due to undiagnosed protein‑S deficiency and exogenous testosterone.

Anoop, Parameswaran; Malmande, Vithal; Kumar, M. N. Prakash; Rao, Naveen