The article reports on a study of the efficacy of tuberculin purified protein derivative antigens through intralesional immunotherapy in the excision of warts. The result shows significant increase clearances of patients warts after being injected by tuberculin purified protein derivative and concludes also that the prevention of tuberculosis and mandatory Bacillus Calmette-Guérin (BCG) vaccination as the cause of higher rate of clearance of warts of patients in South India.