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- Title
Genetic variants of phosphodiesterase 4D gene are associated with an enhanced risk for ischemic stroke in young Chinese population.
- Authors
Ying He; Dong Zhi Yang; Hui Yu; Man Yu Li; Qing Chuan Feng; Hong Zheng; He, Ying; Yang, Dong Zhi; Yu, Hui; Li, Man Yu; Feng, Qing Chuan; Zheng, Hong
- Abstract
<bold>Background: </bold>Previous studies have shown that the phosphodiesterase 4D (PDE4D) gene is a susceptibility gene for ischemic stroke (IS) primarily in elder populations. However, few studies have reported the role of the PDE4D gene polymorphisms in a young cohort.<bold>Aims: </bold>To investigate the association between the PDE4D gene polymorphisms and young-onset IS in Chinese population.<bold>Materials and Methods: </bold>A total of 186 young patients (18-45 years) with IS and 232 matched control subjects were recruited. Two SNPs (rs918592 and rs2910829) in PDE4D gene were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Odds ratio and 95% confidence intervals (95% CI) were calculated to test the association between the genetic factors and IS.<bold>Results: </bold>The rs918592A/A genotype frequency and A allele frequency, rs2910829 CT/TT genotype frequency and T allele frequency of young IS group were significantly higher than those of the control group ( P < 0.05). Besides, the frequency of Hap (A-T) was remarkably higher in the young patients than that in the controls (OR =4.047, 95% CI: 3.521-4.652). Hap (A-C) and Hap (G-C) were associated with decreased risk of IS (OR =0.640, 95% CI: 0.452-0.906; OR =0.675, 95% CI: 0.466-0.978, respectively).<bold>Conclusions: </bold>Our findings suggest that the rs918592 and rs2910829 polymorphisms and haplotypes of PDE4D gene are significantly associated with IS in Chinese young population.
- Subjects
PHOSPHODIESTERASES; STROKE risk factors; GENETIC polymorphisms; CHINESE people; POLYMERASE chain reaction; DISEASES; CEREBRAL ischemia; DISEASE susceptibility; ESTERASES; STROKE
- Publication
Neurology India, 2013, Vol 61, Issue 1, p21
- ISSN
0028-3886
- Publication type
Academic Journal
- DOI
10.4103/0028-3886.108131