Results
Title

Using susceptibility-weighted images to quantify iron deposition differences in amnestic mild cognitive impairment and Alzheimer's disease.

Authors

Dan Wang; Dan Zhu; Xiao-Er Wei; Yue-Hua Li; Wen-Bin Li; Wang, Dan; Zhu, Dan; Wei, Xiao-Er; Li, Yue-Hua; Li, Wen-Bin

Abstract

Aim: To quantify iron deposition in Alzheimer's disease (AD), amnestic mild cognitive impairment (aMCI), and control individuals using susceptibility weighted imaging (SWI).Materials and Methods: Sixty participants (22 aMCI, 20 AD, 18 normal controls) underwent conventional magnetic resonance imaging (MRI) and SWI using axial/oblique coronal sequences. Phase images were used to calculate bilateral iron deposition in 18 regions of interest (ROI). The radian angle value was calculated and compared between the three participant groups.Results: The difference in radian angle value was significant between the aMCI and control groups in the left (L)-hippocampus, L-head of the caudate nucleus, R-lenticular nucleus, L-lenticular nucleus (P =0.02239, Conclusion: Iron deposition in the hippocampus, head of the caudate nucleuslenticular nucleus, and thalamus are significantly different between individuals with aMCI, AD, and controls. The thalamus is a particularly sensitive area. Using SWI to quantify the iron deposition is a useful tool in detecting aMCI and AD.

Subjects

ALZHEIMER'S disease; IRON; AMNESTIC mild cognitive impairment; MAGNETIC resonance imaging; HIPPOCAMPUS (Brain)

Publication

Neurology India, 2013, Vol 61, Issue 1, p26

ISSN

0028-3886

Publication type

Academic Journal

DOI

10.4103/0028-3886.107924