Works matching DE "RAF genes"

Results: 88

Anti-apoptotic BCL-2 proteins govern cellular outcome following B-RAFV600E inhibition and can be targeted to reduce resistance.

Published in:

Oncogene, 2015, v. 34, n. 7, p. 857, doi. 10.1038/onc.2014.21

By:

Serasinghe, M N;
Missert, D J;
Asciolla, J J;
Podgrabinska, S;
Wieder, S Y;
Izadmehr, S;
Belbin, G;
Skobe, M;
Chipuk, J E

Publication type:

Article

Molecular Alterations in Partially-Encapsulated or Well-Circumscribed Follicular Variant of Papillary Thyroid Carcinoma.

Published in:

Thyroid, 2013, v. 23, n. 10, p. 1256, doi. 10.1089/thy.2013.0018

By:

Howitt, Brooke E.;
Jia, Yonghui;
Sholl, Lynette M.;
Barletta, Justine A.

Publication type:

Article

The importance of Raf dimerization in cell signaling.

Published in:

Small GTPases, 2013, v. 4, n. 3, p. 180, doi. 10.4161/sgtp.26117

By:

Freeman, Alyson K;
Ritt, Daniel A;
Morrison, Deborah K

Publication type:

Article

Raf kinases in signal transduction and interaction with translation machinery.

Published in:

Biomolecular Concepts, 2013, v. 4, n. 4, p. 391, doi. 10.1515/bmc-2013-0003

By:

Migliaccio, Nunzia;
Sanges, Carmen;
Ruggiero, Immacolata;
Martucci, Nicola M.;
Rippa, Emilia;
Arcari, Paolo;
Lamberti, Annalisa

Publication type:

Article

T cell leukemia control via Ras-Raf pathway inhibition with peptides.

Published in:

Journal of Medicine & Life, 2017, v. 10, n. 3, p. 172

By:

G., Marin;
H., Bruzzoni-Giovanelli;
G., Schinella

Publication type:

Article

Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de-differentiated state.

Published in:

Molecular Systems Biology, 2017, v. 13, n. 1, p. n/a, doi. 10.15252/msb.20166796

By:

Fallahi‐Sichani, Mohammad;
Becker, Verena;
Izar, Benjamin;
Baker, Gregory J;
Lin, Jia‐Ren;
Boswell, Sarah A;
Shah, Parin;
Rotem, Asaf;
Garraway, Levi A;
Sorger, Peter K

Publication type:

Article

An amino-terminal BRAF deletion accounting for acquired resistance to RAF/EGFR inhibition in colorectal cancer.

Published in:

Cold Spring Harbor Molecular Case Studies, 2020, v. 6, n. 4, p. 1, doi. 10.1101/mcs.a005140

By:

Tung, Jack K.;
Neishaboori, Nastaran;
Haraldsdottir, Sigurdis;
Suarez, Carlos J.

Publication type:

Article

CInQ-03, a novel allosteric MEK inhibitor, suppresses cancer growth in vitro and in vivo.

Published in:

Carcinogenesis, 2013, v. 34, n. 5, p. 1134, doi. 10.1093/carcin/bgt015

By:

Kim, Dong Joon;
Lee, Mee-Hyun;
Reddy, Kanamata;
Li, Yani;
Lim, Do Young;
Xie, Hua;
Lee, Sung-Young;
Yeom, Young Il;
Bode, Ann M.;
Dong, Zigang

Publication type:

Article

The BH3-mimetic ABT-737 sensitizes human melanoma cells to apoptosis induced by selective BRAF inhibitors but does not reverse acquired resistance.

Published in:

Carcinogenesis, 2013, v. 34, n. 2, p. 237, doi. 10.1093/carcin/bgs330

By:

Wroblewski, David;
Mijatov, Branka;
Mohana-Kumaran, Nethia;
Lai, Fritz;
Gallagher, Stuart J.;
Haass, Nikolas K.;
Zhang, Xu Dong;
Hersey, Peter

Publication type:

Article

Enhancing sorafenib-mediated sensitization to gemcitabine in experimental pancreatic cancer through EMAP II.

Published in:

Journal of Experimental & Clinical Cancer Research (17569966), 2013, v. 32, n. 1, p. 1, doi. 10.1186/1756-9966-32-12

By:

Awasthi, Niranjan;
Changhua Zhang;
Hinz, Stefan;
Schwarz, Margaret A.;
Schwarz, Roderich E.

Publication type:

Article

Geographic analysis of RKIP expression and its clinical relevance in colorectal cancer.

Published in:

British Journal of Cancer, 2013, v. 108, n. 10, p. 2088, doi. 10.1038/bjc.2013.197

By:

Koelzer, V H;
Karamitopoulou, E;
Dawson, H;
Kondi-Pafiti, A;
Zlobec, I;
Lugli, A

Publication type:

Article

Rare BRAF mutations in melanoma patients: implications for molecular testing in clinical practice.

Published in:

British Journal of Cancer, 2013, v. 108, n. 10, p. 2164, doi. 10.1038/bjc.2013.143

By:

Heinzerling, L;
Kühnapfel, S;
Meckbach, D;
Baiter, M;
Kaempgen, E;
Keikavoussi, P;
Schuler, G;
Agaimy, A;
Bauer, J;
Hartmann, A;
Kiesewetter, F;
Schneider-Stock, R

Publication type:

Article

The prognostic role of KRAS, BRAF, PIK3CA and PTEN in colorectal cancer.

Published in:

British Journal of Cancer, 2013, v. 108, n. 10, p. 2153, doi. 10.1038/bjc.2013.212

By:

Eklöf, V;
Wikberg, M L;
Edin, S;
Dahlin, A M;
Jonsson, B-A;
Öberg, Å;
Rutegård, J;
Palmqvist, R

Publication type:

Article

In vivo RAF signal transduction as a potential biomarker for sorafenib efficacy in patients with neuroendocrine tumours.

Published in:

British Journal of Cancer, 2013, v. 108, n. 6, p. 1298, doi. 10.1038/bjc.2013.64

By:

Quintela-Fandino, M;
Krzyzanowska, M;
Duncan, G;
Young, A;
Moore, M J;
Chen, E X;
Stathis, A;
Colomer, R;
Petronis, J;
Grewal, M;
Webster, S;
Wang, L;
Siu, L L

Publication type:

Article

Omega-3 and omega-6 PUFAs induce the same GPR120-mediated signalling events, but with different kinetics and intensity in Caco-2 cells.

Published in:

Lipids in Health & Disease, 2013, v. 12, n. 1, p. 1, doi. 10.1186/1476-511X-12-101

By:

Mobraten, Kaia;
Haug, Trude M.;
Kleiveland, Charlotte R.;
Lea, Tor

Publication type:

Article

Regulation of RAF protein kinases in ERK signalling.

Published in:

Nature Reviews Molecular Cell Biology, 2015, v. 16, n. 5, p. 281, doi. 10.1038/nrm3979

By:

Lavoie, Hugo;
Therrien, Marc

Publication type:

Article

Follicular variant of papillary thyroid carcinoma with B-type RafV600E showing higher frequency of suspicious sonographic features and multifocality.

Published in:

Head & Neck, 2015, v. 37, n. 11, p. 1590, doi. 10.1002/hed.23793

By:

Shin, Dong Yeob;
Kim, Kwang Joon;
Chang, Sooyun;
Kim, Hyunki;
Hwang, Sena;
Kim, Wonjin;
Bae, Jaehyun;
Park, Seulkee;
Kang, Sang ‐ Wook;
Chung, Woong Youn;
Lee, Eun Jig

Publication type:

Article

Up-regulation of Ras/Raf/ERK1/2 signaling impairs cultured neuronal cell migration, neurogenesis, synapse formation, and dendritic spine development.

Published in:

Brain Structure & Function, 2013, v. 218, n. 3, p. 669, doi. 10.1007/s00429-012-0420-7

By:

Yang, Kun;
Cao, Fujiang;
Sheikh, Ashfaq;
Malik, Mazhar;
Wen, Guang;
Wei, Hongen;
Ted Brown, W.;
Li, Xiaohong

Publication type:

Article

Identification of a novel MTAP-RAF1 fusion in a soft tissue sarcoma.

Published in:

Diagnostic Pathology, 2018, v. 13, n. 1, p. N.PAG, doi. 10.1186/s13000-018-0759-z

By:

Hicks, J. Kevin;
Henderson-Jackson, Evita;
Duggan, Julia;
Joyce, David M.;
Brohl, Andrew S.

Publication type:

Article

Anti-inflammatory effects of dabrafenib in vitro and in vivo.

Published in:

Canadian Journal of Physiology & Pharmacology, 2017, v. 95, n. 6, p. 697, doi. 10.1139/cjpp-2016-0519

By:

Lee, In-Chul;
Kim, Jongdoo;
Bae, Jong-Sup

Publication type:

Article

The important roles of RET, VEGFR2 and the RAF/MEK/ERK pathway in cancer treatment with sorafenib.

Published in:

Acta Pharmacologica Sinica, 2012, v. 33, n. 10, p. 1311, doi. 10.1038/aps.2012.76

By:

Mao, Wei-feng;
Shao, Min-hua;
Gao, Pin-ting;
Ma, Ji;
Li, Hui-juan;
Li, Gai-ling;
Han, Bao-hui;
Yuan, Chong-gang

Publication type:

Article

Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond.

Published in:

Nature Reviews Cancer, 2014, v. 14, n. 7, p. 455, doi. 10.1038/nrc3760

By:

Holderfield, Matthew;
Deuker, Marian M.;
McCormick, Frank;
McMahon, Martin

Publication type:

Article

Therapeutics: iterations of BRAF.

Published in:

2012

By:

Alderton, Gemma K.

Publication type:

journal article

TRPC1/3/6 inhibition attenuates the TGF‐β1‐induced epithelial–mesenchymal transition in gastric cancer via the Ras/Raf1/ERK signaling pathway.

Published in:

Cell Biology International, 2018, v. 42, n. 8, p. 975, doi. 10.1002/cbin.10963

By:

Ge, Pengbo;
Wei, Linting;
Zhang, Mingkai;
Hu, Baoguang;
Wang, Kai;
Li, Yanbin;
Liu, Shuaichen;
Wang, Jianping;
Li, Yuming

Publication type:

Article

αC IN, αC OUT-that's what it's all about.

Published in:

Pigment Cell & Melanoma Research, 2017, v. 30, n. 2, p. 177, doi. 10.1111/pcmr.12549

By:

Hartsough, Edward J.;
Vido, Michael J.

Publication type:

Article

Clinical and therapeutic implications of BRAF mutation heterogeneity in metastatic melanoma.

Published in:

Pigment Cell & Melanoma Research, 2017, v. 30, n. 2, p. 233, doi. 10.1111/pcmr.12569

By:

Mesbah Ardakani, Nima;
Leslie, Connull;
Grieu ‐ Iacopetta, Fabienne;
Lam, Wei ‐ Sen;
Budgeon, Charley;
Millward, Michael;
Amanuel, Benhur

Publication type:

Article

G12D NRAS and kinase-dead BRAF cooperate to drive naevogenesis and melanomagenesis.

Published in:

Pigment Cell & Melanoma Research, 2014, v. 27, n. 6, p. 1162, doi. 10.1111/pcmr.12293

By:

Pedersen, Malin;
Viros, Amaya;
Cook, Martin;
Marais, Richard

Publication type:

Article

Resistance to vemurafenib resulting from a novel mutation in the BRAFV600 E kinase domain.

Published in:

Pigment Cell & Melanoma Research, 2014, v. 27, n. 1, p. 124, doi. 10.1111/pcmr.12171

By:

Wagenaar, Timothy R.;
Ma, Leyuan;
Roscoe, Benjamin;
Park, Sung Mi;
Bolon, Daniel N.;
Green, Michael R.

Publication type:

Article

Selective RAF inhibitor impairs ERK1/2 phosphorylation and growth in mutant NRAS, vemurafenib-resistant melanoma cells.

Published in:

Pigment Cell & Melanoma Research, 2013, v. 26, n. 4, p. 509, doi. 10.1111/pcmr.12092

By:

Le, Kaitlyn;
Blomain, Erik S.;
Rodeck, Ulrich;
Aplin, Andrew E.

Publication type:

Article

Senescence-escape in melanoma.

Published in:

Pigment Cell & Melanoma Research, 2012, v. 25, n. 4, p. 408, doi. 10.1111/j.1755-148X.2012.01021.x

By:

Liu, Wenjin;
Sharpless, Norman E.

Publication type:

Article

Active surrender.

Published in:

Pigment Cell & Melanoma Research, 2012, v. 25, n. 3, p. 292, doi. 10.1111/j.1755-148X.2012.00991.x

By:

Collisson, Eric A.

Publication type:

Article

Stimulation of β-adrenergic receptors plays a protective role via increased expression of RAF-1 and PDX-1 in hyperglycemic rat pancreatic islet (RIN-m5F) cells.

Published in:

2017

By:

Safi, Sher Zaman;
Qvist, Rajes;
Ong, Gracie;
Karimian, Hamed;
Imran, Muhammad;
Shah, Ikram

Publication type:

journal article

Molecular mechanisms of asymmetric RAF dimer activation.

Published in:

Biochemical Society Transactions, 2014, v. 42, n. 4, p. 784, doi. 10.1042/BST20140025

By:

Jambrina, Pablo G.;
Bohuszewicz, Olga;
Buchete, Nicolae-Viorel;
Kolch, Walter;
Rosta, Edina

Publication type:

Article

Tumor adaptation and resistance to RAF inhibitors.

Published in:

Nature Medicine, 2013, v. 19, n. 11, p. 1401, doi. 10.1038/nm.3392

By:

Lito, Piro;
Rosen, Neal;
Solit, David B

Publication type:

Article

Mécanismes de résistances aux inhibiteurs de RAF : revue de la littérature.

Published in:

Oncologie (Tech Science Press), 2012, v. 14, n. 1, p. 2, doi. 10.1007/s10269-011-2100-2

By:

Rousseau pour l'Aerio, B.

Publication type:

Article

Membrane-associated Ras dimers are isoform-specific: K-Ras dimers differ from H-Ras dimers.

Published in:

Biochemical Journal, 2016, v. 473, n. 12, p. 1719, doi. 10.1042/BCJ20160031

By:

Hyunbum Jang;
Muratcioglu, Serena;
Gursoy, Attila;
Keskin, Ozlem;
Nussinov, Ruth

Publication type:

Article

Pentoxifylline inhibits hepatic stellate cells proliferation via the Raf/ ERK pathway.

Published in:

APMIS, 2012, v. 120, n. 7, p. 572, doi. 10.1111/j.1600-0463.2011.02868.x

By:

Zhang, Di;
Jiang, Huiqing;
Wang, Yan;
Ma, Junji

Publication type:

Article

Combination therapies to inhibit the RAF/MEK/ERK pathway in melanoma: we are not done yet.

Published in:

Frontiers in Oncology, 2015, p. 1, doi. 10.3389/fonc.2015.00161

By:

McArthur, Grant A.;
Sullivan, Ryan J.;
Lito, Piro;
Smalley, Keiran

Publication type:

Article

A novel long non-coding RNA lnc-GNAT1-1 is low expressed in colorectal cancer and acts as a tumor suppressor through regulating RKIP-NF-κB-Snail circuit.

Published in:

Journal of Experimental & Clinical Cancer Research (17569966), 2016, v. 35, p. 1, doi. 10.1186/s13046-016-0467-z

By:

Chunxiang Ye;
Zhanlong Shen;
Bo Wang;
Yansen Li;
Tao Li;
Yang Yang;
Kewei Jiang;
Yingjiang Ye;
Shan Wang

Publication type:

Article

Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors.

Published in:

PLoS ONE, 2017, v. 12, n. 10, p. 1, doi. 10.1371/journal.pone.0185862

By:

Merchant, Mark;
Moffat, John;
Schaefer, Gabriele;
Chan, Jocelyn;
Wang, Xi;
Orr, Christine;
Cheng, Jason;
Hunsaker, Thomas;
Shao, Lily;
Wang, Stephanie J.;
Wagle, Marie-Claire;
Lin, Eva;
Haverty, Peter M.;
Shahidi-Latham, Sheerin;
Ngu, Hai;
Solon, Margaret;
Eastham-Anderson, Jeffrey;
Koeppen, Hartmut;
Huang, Shih-Min A.;
Schwarz, Jacob

Publication type:

Article

B-RAF and its novel negative regulator reticulocalbin 1 (RCN1) modulates cardiomyocyte hypertrophy.

Published in:

Cardiovascular Research, 2014, v. 102, n. 1, p. 88, doi. 10.1093/cvr/cvu024

By:

Kramann, Nadine;
Hasenfuß, Gerd;
Seidler, Tim

Publication type:

Article

C- Raf deficiency leads to hearing loss and increased noise susceptibility.

Published in:

Cellular & Molecular Life Sciences, 2015, v. 72, n. 20, p. 3983, doi. 10.1007/s00018-015-1919-x

By:

Iriarte Rodríguez, Rocío;
Magariños, Marta;
Pfeiffer, Verena;
Rapp, Ulf;
Varela-Nieto, Isabel

Publication type:

Article

RKIP and 14-3-3ε Exert an Opposite Effect on Human Gastric Cancer Cells SGC7901 by Regulating the ERK/MAPK Pathway Differently.

Published in:

Digestive Diseases & Sciences, 2013, v. 58, n. 2, p. 389, doi. 10.1007/s10620-012-2341-y

By:

Yan, Lu;
Gu, Huan;
Li, Jia;
Xu, Meihua;
Liu, Ting;
Shen, Yueming;
Chen, Bolin;
Zhang, Guiying

Publication type:

Article

Complete clinical regression of a BRAF V600E-mutant pediatric glioblastoma multiforme after BRAF inhibitor therapy.

Published in:

BMC Cancer, 2014, v. 14, n. 1, p. 1, doi. 10.1186/1471-2407-14-258

By:

Robinson, Giles W.;
Orr, Brent A.;
Gajjar, Amar

Publication type:

Article

Severe pan-uveitis in a patient treated with vemurafenib for metastatic melanoma.

Published in:

BMC Cancer, 2013, v. 13, n. 1, p. 1, doi. 10.1186/1471-2407-13-561

By:

EJ Wolf, Sanne;
Meenken, Christina;
Moll, Annette C.;
Haanen, John B.;
van der Heijden, Michiel S.

Publication type:

Article

Mapping the interactome of overexpressed RAF kinase inhibitor protein in a gastric cancer cell line.

Published in:

2013

By:

Huan Gu;
Xianquan Zhan;
Guiying Zhang;
Lu Yan;
Cho, William C. S.;
Maoyu Li;
Ting Liu;
Zhuchu Chen;
Gu, Huan;
Zhan, Xianquan;
Zhang, Guiying;
Yan, Lu;
Cho, William Cs;
Li, Maoyu;
Liu, Ting;
Chen, Zhuchu

Publication type:

journal article

BRAF V600E-Negative Hairy Cell Leukaemia.

Published in:

Case Reports in Hematology, 2013, p. 1, doi. 10.1155/2013/513049

By:

Langabeer, Stephen E.;
O'Brien, David;
McElligott, Anthony M.;
Lavin, Michelle;
Browne, Paul V.

Publication type:

Article

TRAF3IP2 gene and systemic lupus erythematosus: association with disease susceptibility and pericarditis development.

Published in:

Immunogenetics, 2013, v. 65, n. 10, p. 703, doi. 10.1007/s00251-013-0717-6

By:

Perricone, Carlo;
Ciccacci, Cinzia;
Ceccarelli, Fulvia;
Fusco, Davide;
Spinelli, Francesca;
Cipriano, Enrica;
Novelli, Giuseppe;
Valesini, Guido;
Conti, Fabrizio;
Borgiani, Paola

Publication type:

Article

CD45RAFoxp3 regulatory T cells have a negative impact on the clinical outcome of head and neck squamous cell carcinoma.

Published in:

Cancer Immunology, Immunotherapy, 2017, v. 66, n. 10, p. 1275, doi. 10.1007/s00262-017-2021-z

By:

Ihara, Fumie;
Sakurai, Daiju;
Horinaka, Atsushi;
Makita, Yuji;
Fujikawa, Akira;
Sakurai, Toshioki;
Yamasaki, Kazuki;
Kunii, Naoki;
Motohashi, Shinichiro;
Nakayama, Toshinori;
Okamoto, Yoshitaka

Publication type:

Article

The Ras/ MAPK pathway and hepatocarcinoma: pathogenesis and therapeutic implications.

Published in:

European Journal of Clinical Investigation, 2015, v. 45, n. 6, p. 609, doi. 10.1111/eci.12441

By:

Delire, Bénédicte;
Stärkel, Peter

Publication type:

Article