Purpose: This study was, done to develop a model which explains factors influencing caring behavior of mothers who have children with disabilities, and to verify the appropriateness of the model and the relationship among variables. Methods: The participants in the research were the mothers who had a 3 to 12 yr-old children with disabilities. The data were collected from 451 mothers through self-reported questionnaires from July 14 to 31, 2008. A total of the 371 data sets were analyzed using SPSS/WIN 11.5 and AMOS 5.0 version. Results: The children's behavior characteristics, social support, objective burden and parenting self-esteem had an impact on the mothers' caring behavior. Especially, parenting self- esteem including parenting satisfaction and self-efficacy was the most influential factor. These variables explained 77% of the mothers' caring behavior for these children. Conclusion: The results suggest that some strategies for promoting mothers' parenting self-esteem focused on parenting satisfaction and self-efficacy should be developed in order to help mothers in caring for their child who is disabled.