To investigate relationship between chronic ache, depression and anxiety. The study looked into correlations between chronic pain, sadness, and anxiety using data from several Karachi regions. There are 1490 people in the entire sample. The Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM IV)-based Composite International Diagnostic Interview was used to assess depression and/or anxiety (CIDI, version 2.1). The Quick Inventory of Depressed Symptomatology-Self-Report, which excludes questions related to pain, was used to measure the severity of depressive symptoms. We employed self-report questionnaires to evaluate mental health. According to our findings, 326 people showed no signs of psychopathology, 314 had remitted depressive or anxiety disorders, and 198 had a current depressive disorder, which was then followed by a current anxiety illness. Maximum of 381 people reported having current concurrent depression and anxiety, while 392 people in the entire group took antidepressants. 90 (5.7%) of the 1490 individuals made no mention of any pain symptoms. Maximum participants (700) reported experiencing musculoskeletal discomfort, which was followed by gastro-intestinal pain (400), and cardiorespiratory pain (300). It has been shown that anxiety and depression are also related to the site of pain.