The relationship between blood uric acid levels and non-alcoholic fatty liver disease in patients with type H hypertension.

ZHANG Yao; HUO Yingxin; ZHAO Wei; TANG Rongjie; LIAN Qiufang

Objective To explore the relationship between blood uric acid levels and non-alcoholic fatty liver disease in patients with type H hypertension. Methods The clinical data of 284 patients with type H hypertension admitted to the Cardiovascular Department, Xianyang Hospital, Yan'an University in 2022 were collected and retrospectively reviewed. The patients were divided into NAFLD group (n = 88) and normal group (n = 196) according to whether they had NAFLD. The general information and laboratory indicators were compared between the two groups. Multivariate logistic regression analysis was conducted to explore the influencing factors of NAFLD in H-type hypertension patients. The draw ROC curves were plotted to observe the role of SUA in predicting NAFLD and select the optimal cutoff value based on the maximum Youden index. Results The NAFLD group demonstrated higher levels in body mass index, systolic blood pressure, diastolic blood pressure, total cholesterol, triglycerides, low-density lipoprotein cholesterol, SUA, γ-Glutamyl transpeptidase and alanine aminotransferase compared to the normal group, but significantly lower levels at age and high-density lipoprotein cholesterol(P < 0.05). The multivariate logistic regression analysis showed that elevated levels of BMI(OR = 1.173, 95%CI: 1.066 ~ 1.291), SUA(OR = 1.005, 95%CI: 1.001 ~ 1.010), and TG(OR = 1.929, 95%CI: 1.042 ~ 3.574)were risk factors for NAFLD in patients with type H hypertension (P < 0.05). The ROC curves showed that the area under the curve (AUC) of SUA, TG, BMI, and their combination were 0.709, 0.707, 0.750, and 0.796, respectively. Conclusion type H hypertensive NAFLD patients have high levels of BMI, SUA, TG compared to non-NAFLD patients. Elevated SUA is a risk factor for type H hypertensive NAFLD patients, with SUA > 337 μmol/L as a significant value for predicting NAFLD.

NON-alcoholic fatty liver disease; HDL cholesterol; LDL cholesterol; DISEASE risk factors; DIASTOLIC blood pressure

Journal of Practical Medicine / Shiyong Yixue Zazhi, 2024, Vol 40, Issue 18, p2561

1006-5725

Academic Journal

10.3969/j.issn.1006-5725.2024.18.009