Exploration of the relationship between gut microbial dysbiosis and cholesterol stones based on the theory of "earth stagnation wood depression".

FENG Binbin; HAN Junquan; YANG Chaoshuai; GAO Tianying; RAN Jiawen; WANG Hong

Cholesterol stones are a common occurrence worldwide. Surgery is an effective way to treat cholesterol stones, but some patients may experience stone regeneration after surgery, and there is still no effective prevention and treatment strategy. Cholesterol supersaturation in bile is a prerequisite for the formation of cholesterol stones, but the specific pathogenesis remains poorly understood. In recent years, studies have found that intestinal dysbacteriosis is an important pathological basis for abnormal lipid metabolism closely related to the formation of cholesterol stones, and maintaining intestinal flora homeostasis can effectively prevent and treat cholesterol stones by taking intestinal flora as the starting point. "Earth stagnation and wood depression" is the pathological process of spleen and soil stagnation, and anti-insult liver wood result in liver wood stagnation, which plays an important role in the pathogenesis of cholesterol stones. By discussing the relationship between "earth stagnation" and intestinal flora, this paper proposes the important role of traditional Chinese medicine spleen soil in cholesterol stones and provides a new interpretation of the role of the "earth stagnation and wood depression" theory in the pathogenesis of cholesterol stones. At the same time, it is proposed that gallbladder treatment should be achieved by thinning the liver and treating the spleen, which can improve the imbalance of intestinal flora and regulate lipid metabolism to prevent and control the formation of cholesterol stones and may provide new prevention and treatment ideas for cholesterol stones.

CHOLESTEROL; CHINESE medicine; LIPID metabolism; DYSBIOSIS; METABOLIC regulation

Journal of Beijing University of Traditional Chinese Medicine, 2023, Vol 46, Issue 7, p980

1006-2157

Academic Journal

10.3969/j.issn.1006-2157.2023.07.015