Synthesis of acetamide derivatives of 1,2,4-triazole bearing azinane and their binding interactions with bovine serum albumin using spectroscopic techniques.

IQBAL, Javed; UR-REHMAN, Aziz; ABBASI, Muhammad Athar; SIDDIQUI, Sabahat Zahra; KHALID, Hira; LAULLOO, Sabina Jhaumeer; JOONDAN, Nausheen; TAUPASS, Aniisah Banu; RASOOL, Shahid; Ali SHAH, Syed Adnan

A new series of acetamide derivatives containing 1,2,4-triazole and azinane moieties has been synthesized and characterized using 1 H NMR, 13 C NMR, IR, and EI-MS spectroscopic analysis. The intermediate triazole was synthesized through a sequential synthesis of carboxylate and carbohydrazide. The bovine serum albumin (BSA) binding of the newly synthesized 1,2,4-triazole derivatives was evaluated along with thermodynamics, site-selective binding, and synchronous study. The results obtained by BSA binding as well as thermodynamic studies justify that all the compounds show spontaneous interaction with BSA and could be effectively distributed and eliminated from the body. Therefore, the triazole-based analogs might be a useful strategy for designing new drug systems.

ACETAMIDE derivatives; TRIAZOLES; ALBUMINS; CARBOXYLATES; NUCLEAR magnetic resonance

Turkish Journal of Chemistry, 2018, Vol 42, Issue 6, p1459

1300-0527

Academic Journal

10.3906/kim-1801-95