Effective treatment of collecting duct carcinoma in a recipient of a kidney transplant: A case report.

DE ASSIS, TABATA CAROLINA FARIA NASCIMENTO; RAPATONI, LIANE; SEGATO, FLAVIO NOGUEIRA; PONTES, BARBHARA THAIS MACIEL; MUGLIA, VALDAIR FRANCISCO; NETO, MIGUEL MOYSES; ROMAO, ELEN ALMEIDA

Collecting duct carcinoma (CDC) is a rare disease associated with a high mortality rate. The present study describes the case of a recipient of a kidney transplant with metastatic allograft CDC whose treatment was successful. The patient underwent nephrectomy, and chemotherapy with gemcitabine and cisplatin, while undergoing haemodialysis treatment and remained in remission after 6 years of follow-up. There is a lack of information about the treatment and clinical management of CDC; however, the combination of gemcitabine and cisplatin remains as first-line therapy. The challenge of this case was integrating chemotherapy sessions with dialysis therapy to maintain the effectiveness, tolerability and safety of the oncological treatment. In the present case report, the success of chemotherapy with gemcitabine and cisplatin was demonstrated in a metastatic renal allograft CDC in a patient with end-stage renal disease, with few side effects and no recurrence of the disease 6 years after the end of treatment.

END of treatment; RENAL cell carcinoma; CHRONIC kidney failure; KIDNEY transplantation; CISPLATIN

Oncology Letters, 2024, Vol 28, Issue 5, p1

1792-1074

Academic Journal

10.3892/ol.2024.14661