Results
Title

ALU repeat as potential molecular marker in the detection and prognosis of different cancer types: A systematic review.

Authors

Shaban, Semaa A.; Al-Rahim, Aya M.; Suleiman, Ahmed Abduljabbar

Abstract

Cancer is a major health issue worldwide. cfDNA integrity has been reported as a potential diagnostic molecular marker for different types of cancer, identifying the importance of liquid biopsy. The aim of this review was to evaluate the prognostic and diagnostic performance of Arthrobacter luteus (ALU) repeat in tumor. Following a thorough review of the literature published from January, 2000 to September 2021, 36 studies were included. All of the study descriptions were analyzed. According to several studies, there were increased concentrations of ALU repetitive elements in cancer patients, while these concentrations were decreased in control, benign, different cancer stage, and other diseases. The total ALU (115 and 247) sequence levels are potential biomarkers for the purpose of investigations and cancer prognosis.

Subjects

CANCER prognosis; ARTHROBACTER; TUMOR classification; CELL-free DNA

Publication

Molecular & Clinical Oncology, 2022, Vol 16, Issue 4, pN.PAG

ISSN

2049-9450

Publication type

Academic Journal

DOI

10.3892/mco.2022.2519