LncRNA EGFR‑AS1 promotes lung cancer cell proliferation, invasion and metastasis via regulation of miR‑449a/HDAC1.

Huang, Jie; Wang, Baoqing; Wu, Qin; Wang, Liming; Guan, Chao

There is increasing evidence that long non-coding (lnc)RNA EGFR-AS1 is involved in the development of numerous types of cancer, including non-small-cell lung cancer (NSCLC). The Cancer Genome Atlas (TCGA) demonstrates that EGFR-AS1 is highly expressed in NSCLC. Downregulation of EGFR-AS1 in A549 and PC9 NSCLC cells demonstrates inhibition of NSCLC proliferation, invasion and metastasis. The present study demonstrated that lncRNA EGFR-AS1 was essential for the development of NSCLC through its function as a competitive endogenous RNA binding to miR-449a and upregulating histone deacetylase 1. In brief, it identified a novel signaling pathway that mediated the invasion and metastasis of NSCLC and may therefore provide a new treatment target for NSCLC.

COMPETITIVE endogenous RNA; LINCRNA; NON-small-cell lung carcinoma; CANCER cell proliferation; HISTONE deacetylase

Experimental & Therapeutic Medicine, 2025, Vol 29, Issue 2, pN.PAG

1792-0981

Academic Journal

10.3892/etm.2024.12777