The predictive role of inflammatory biomarkers based on first trimester complete blood count parameters for the risk of HELLP syndrome: A case-control study.

OZKAN, Sadullah; FİRATLİGİL, Fahri Burcin; KURT, Dilara; KURT, Ahmet; TOPKARA SUCU, Serap; SUCU, Sadun; DERELİ, Murat Levent; CELEN, Sevki

Aim: To conclude the predictive role of inflammatory biomarkers based on first trimester complete blood count parameters for the risk of HELLP syndrome. Materials and Methods: This case-control study was included 45 of 73 pregnant women with HELLP syndrome. Clinical data and laboratory results were retrieved by medical and hospital records. We compared the inflammatory biomarkers based on first trimester complete blood count parameters for the risk of HELLP syndrome. Results: We recruited 45 cases (pregnant women with HELLP syndrome) and 45 controls (healthy pregnant women), matched for body mass index, gravidity, parity and gestational week. The lymphocyte, platelets - lymphocyte ratio, neutrophil - lymphocyte ratio and systemic inflammation index values were statistically significant between the groups in the first trimester blood test results. There was no significant difference in systemic inflammation response index and pan-immune inflammation value between groups in the first trimester blood test results. Conclusions: The main problem with HELLP syndrome is that it does not occur all at once, but that there is a certain inflammatory process. We can relate this process to the inflammatory parameters in the first trimester. Although this study does not aim to use the inflammatory markers for the diagnosis and treatment of HELLP syndrome, inflammatory parameters can be a trigger for the development of HELLP syndrome. However, none of the investigated indices proved to be an effective predictor in the first trimester. Nevertheless, simple and non-invasive predictive indices can be valuable tools for the prediction and management of HELLP syndrome.

HELLP syndrome; PREGNANT women; BODY mass index; INFLAMMATION; BLOOD testing

Jinekoloji-Obstetrik & Neonatoloji Tip Dergisi, 2024, Vol 21, Issue 4, p345

1304-5512

Academic Journal

10.38136/jgon.1556762