Primary solid pseudopapillary tumor of the ovary: a case report.

Juhun Lee; Jieon Lee; Hyun-Jung Lee

Solid pseudopapillary neoplasms (SPNs) are rare and mainly originate from the pancreas. SPNs originating from the ovary (SPN-O) are extremely rare, and only 13 cases have been reported in the English literature since 2010. We report a 31-year-old woman with SPN-O accompanied by multiple metastases in the abdominal cavity. The patient underwent laparoscopic unilateral ovarian cystectomy in another medical institution due to an unknown pathologic diagnosis approximately 4.5 years before the presentation. Whether the surgical spillage occurred or not in this laparoscopic surgery was unclear. The patient underwent staging surgery and cytoreduction, including total hysterectomy, bilateral salpingo-oophorectomy, lymphadenectomy from both pelvic sides up to the para-aortic level, infracolic omentectomy, appendectomy, and multiple peritoneal biopsies. Furthermore, the multidisciplinary board decided on adjuvant chemotherapy, 5-fluorouracil and cisplatin regimen (D1, cisplatin 60 mg/m2 intravenously; D1-D3, 5-fluorouracil 825 mg/m2 intravenously), because a microscopic metastasis was discovered in the peritoneum near the appendix. Next-generation sequencing showed some pathologic mutations of oncogenes/cancerassociated genes, including CTNNB1 and TP53. This is the 14th case of SPN-O and the first one to demonstrate the TP53 pathogenic mutant variant in SPN-O.

OVARIAN tumors; PANCREATIC tumors; CYTOREDUCTIVE surgery; ABDOMEN; ADJUVANT chemotherapy; LAPAROSCOPIC surgery

Journal of Gynecologic Oncology, 2024, Vol 35, p58

2005-0380

Academic Journal

10.3802/jgo.2024.35.S2.P77