We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Weekly paclitaxel with pazopanib for heavily treated ovarian cancer.
- Authors
Min Chul Choi; Jung-Yun Lee; Jeong-Won Lee
- Abstract
Objective: This study investigated the antitumor activity and safety of weekly paclitaxel with pazopanib to for heavily treated ovarian cancer in real-world practice. Methods: We conducted a retrospective study of patients with recurrent epithelial ovarian/fallopian tubal/peritoneal cancer treated with weekly paclitaxel with pazopanib at three tertiary institutions in Korea between September 2018 and August 2023. Patients were received paclitaxel 80 mg/m² intravenously on days 1, 8, and 15 every 28 days with pazopanib 800 mg orally daily. The primary endpoints were response rate, progression-free survival (PFS) rate, overall survival (OS) rate and safety. Results: Data were evaluable for 62 patients. During the median follow-up of 6.6 months (range, 0.2-40.7), response rate was 40.3% (25/62). Median PFS was 5.7 months and median OS was 18.8 months. There were 43.5% (27/62) of grade 3/4 adverse events and toxicity-related discontinuations (17.7%). Severe adverse events were gastrointestinal fistula or perforation (7 events) and liver toxicity (5 events), resulting three treatment-related deaths. Conclusion: The weekly paclitaxel with pazopanib could show the favorable response and increased toxicity to the heavily treated ovarian cancer patients.
- Subjects
OVARIAN cancer; PACLITAXEL; PERITONEAL cancer; HEPATOTOXICOLOGY; ANTINEOPLASTIC agents
- Publication
Journal of Gynecologic Oncology, 2024, Vol 35, p36
- ISSN
2005-0380
- Publication type
Academic Journal
- DOI
10.3802/jgo.2024.35.S2.P30