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- Title
Major clinical research advances in gynecologic cancer in 2019.
- Authors
Miseon Kim; Dong Hoon Suh; Kyung-Hun Lee; Keun-Yong Eom; Jung-Yun Lee; Yoo-Young Lee; Hanne Falk Hansen; Mansoor Raza Mirza; Jae-Weon Kim
- Abstract
In 2019, 12 topics were selected as the major research advances in gynecologic oncology. Herein, we first opted to introduce the significant clinical activity of pembrolizumab in women with advanced cervical cancer based on the results of the phase 2 KEYNOTE-158 trial. Thereafter, we reviewed 5 topics, including systemic lymphadenectomy in the advanced stage with no gross residual tumor, secondary cytoreductive surgery in recurrent ovarian cancer according to the results of Gynecologic Oncology Group-213 trial, dose-dense weekly paclitaxel scheduling as first-line chemotherapy, the utility of intraperitoneal therapy in the advanced stage, and an update on poly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer. Additionally, we conducted a thorough review of emerging data from several clinical trials on PARP inhibitors according to drug, target population, and combined usage. For uterine corpus cancer, we reviewed adjuvant therapy for high-risk disease and chemotherapy in advanced/recurrent disease. For the field of radiation oncology, we discussed the utility of neoadjuvant chemotherapy added to chemoradiotherapy and the treatment of radiation-induced cystitis using hyperbaric oxygen. Finally, we discussed the use of individualized therapy with humanized monoclonal antibodies (trastuzumab emtansine and sacituzumab govitecan-hziy) and combination therapy (fulvestrant plus alpesilib, fulvestrant plus anastrozole, and ribociclib plus endocrine therapy) for women with advanced breast cancer.
- Subjects
CYTOREDUCTIVE surgery; GYNECOLOGIC cancer; HORMONE receptor positive breast cancer; BREAST cancer; UTERINE cancer; GYNECOLOGIC oncology; MONOCLONAL antibodies
- Publication
Journal of Gynecologic Oncology, 2020, Vol 31, Issue 3, p1
- ISSN
2005-0380
- Publication type
Academic Journal
- DOI
10.3802/jgo.2020.31.e48